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腰椎融合术后邻近节段退变影响因素的研究进展

2016-10-19胡国鹏张贤

中国医药导报 2016年6期
关键词:影响因素

胡国鹏 张贤

[摘要] 腰椎融合术后邻近节段退变(ASD)指腰椎融合术后融合区域邻近节段(上或下)的退行性病变。近年来在腰椎融合术治疗腰椎退行性疾病得到满意效果并被脊柱外科医生普遍应用的同时,术后ASD越来越受到国内外学者的关注。其中,ASD发生的影响因素逐渐成为研究热点。近年来大多数学者将ASD影响因素分为两类,一类为患者自身因素,包括年龄、性别、绝经期、骨质疏松、早已存在的邻近节段退变及肥胖、吸烟等;另一类为手术相关因素,包括后方棘突韧带复合体的完整性、邻近节段预防性减压、椎弓根螺钉植入位置、矢状面平衡、术中椎间隙的过度撑开、融合方式、融合长度及融合位置等。

[关键词] 腰椎融合术;邻近节段退变;影响因素

[中图分类号] R687.3 [文献标识码] A [文章编号] 1673-7210(2016)02(c)-0050-04

Progress on risk factors for adjacent segment degeneration after lumbar fusion

HU Guopeng1 ZHANG Xian2

1.Nanjing University of Traditional Chinese Medicine, Jiangsu Province, Nanjing 210023, China; 2. Wuxi Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine, Jiangsu Province, Wuxi 214071, China

[Abstract] ASD refers to degeneration of adjacent segment the fusion area (up or down) after lumbar fusion. When lumbar fusion has been widely used in the treatment of lumbar degenerative diseases, ASD related problems are more concerned by clinical doctor. Among them, the risk factors of ASD are becoming a hot spot by basic and clinical research. In recent years the risk factors can be divided into two categories, one is patients' own factors, including age, gender, menopause, osteoporosis, already degeneration of adjacent segment, obesity, smoking, the other kind of factors related to the operation, including the integrity of the rear spine ligament complex, adjacent segment preventive decompression, pedicle screws inserted, sagittal balance, the excessive distraction of the disc space, and length and position of fusion, and so on.

[Key words] Lumbar fusion; Adjacent segment degeneration; Risk factors

歷经100多年的发展,腰椎融合术已逐渐成为治疗退行性腰椎疾病的经典术式。与此同时,随着对脊柱生理功能和生物力学研究的不断深入,许多研究发现腰椎融合后因融合节段运动功能丧失,导致椎间应力传导发生异常改变,邻近节段椎间盘和关节突的压力明显增加,腰椎融合术后邻近节段退变(ASD)逐渐成为腰椎融合术的主要并发症。近年来关于腰椎融合术后ASD的临床报道屡见不鲜,但腰椎融合术后仅部分患者出现邻近节段的退变,因此导致ASD发生的影响因素也引起越来越多学者的关注,并进行了大量的临床随访研究。现将近年来ASD发生影响因素的……

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