杨莉周口市中心医院妇科，河南周口　466000

孕激素后半周期治疗在功血治疗中的应用

杨莉
周口市中心医院妇科，河南周口466000

目的分析孕激素后半周期治疗在功血治疗中的应用。方法选取2014年9月—2015年6月期间该院收治的60例围绝经期功能失调性子宫出血患者，将所有患者随机分为两组，各30例，对照组在刮宫后采用达英-35治疗，观察组则采用安宫黄体酮治疗，分析比较两组治疗有效率、疾病复发率、在治疗期间出现的不规律出血、服药3周后经量恢复正常率及子宫内膜厚度变化。结果观察组治疗有效率为76.67%，低于对照组93.33%，P＜0.05差异有统计学意义；观察组治疗期间的不规律的出血率为26.67%及服药3周后经量恢复正常率为86.67%均高于对照组10.00%和46.67%，P＜0.05，差异有统计学意义；两组治疗后疾病复发率对比，差异无统计学意义，P＞0.05；治疗前，观察组子宫内膜厚度为（12.27±1.53）mm与对照组（12.31±1.26）mm比较，差异无统计学意义，P＞0.05；治疗后，观察组子宫内膜厚度（5.26±1.48）mm低于对照组（7.83±1.12）mm，差异有统计学意义，P＜0.05；观察组并发症发生率为23.33%，显著高于对照组6.67%，P＜0.05差异有统计学意义。结论安宫黄体酮及达英-35在治疗功血中均可有效控制患者出血量及子宫内膜厚度，使患者血液中血红蛋白含量升高，相对而言，达英-35安全性较高。

孕激素；后半周期；功能失调性子宫出血

［Abstract］Objective To analyse the application of metrorrhagia of functional disorder by the progesterone in the second half of the treatment.Methods To selected 60 cases of patients with dysfunctional uterine bleeding of perimenopause at our hospital from the September 2014 to June 2015 randomly divided into two groups，each 30 cases，the control group was treated by Diane-35 after uterine apoxesis，the treatment group was treated by medroxyprogesterone acetate，analysis and comparison of overall response rate，disease relapse rate，irregular bleeding occurs during treatment，taking three weeks to return to normal by the amount and rate of change in endometrial thickness.Results The treatment effective rate of the treatment group was 76.67%that was lower than the 93.33%of the control group，there was statistical significance（P＜0.05）.Irregular bleeding treatment during the observation group was 26.67%and the amount of medication three weeks after normal rate of 86.67%was higher than 10.00%and 46.67%，there was statistical significance（P＜0.05）.Before treatment，the observation group endometrial thickness（12.27±1.53）mm and the control group（12.31±1.26）mm compared，there was no statistical significance（P＞0.05）.Before treatment，to compared the endometrial thickness of them，there was no statistical significance（P＞0.05）.After treatment，the endometrial thickness in the observation group（5.26±1.48）mm lower than the control group（7.83±1.12）mm，there was statistical significance（P＜0.05）.The incidence of complications of the treatment group was 23.33%，that was significantly greater than the 6.67%of the control group，there was statistical significance（P＜0.05）.Conclusion That able to effectively control the amount of bleeding and endometrial thickness of the metrorrhagia of functional disorder by medroxyprogesterone acetate and Diane-35，to increase the hemoglobin in the blood of patients，to relatively speaking，the Diane-35 has higher safety.

［Key words］Progestational hormone，Second half，Dysfunctional uterine bleeding

功能性子宫出血是指由于患者神经内分泌失调所引起的生殖道器质性疾病，多发于青春期和围绝经期，进而导致患者无法正常排卵，使患者体内孕激素水平下降，子宫内膜无法正常分化，造成内膜生长异常［1-2］。……