温晓红辽宁省丹东市第一医院检验科，辽宁丹东　118000

血清降钙素原与超敏C反应蛋白、白细胞计数在儿童急性呼吸道感染中的早期诊断价值

温晓红
辽宁省丹东市第一医院检验科，辽宁丹东118000

目的探究降钙素原（PCT）、超敏C反应蛋白（hs-CRP）与白细胞计数（WBC）在儿童急性呼吸道感染早期诊断中的临床价值。方法收集本院收治的145例被确诊为儿童急性呼吸道感染患儿的临床资料 （细菌感染组48例，支原体感染组39例，病毒感染组58例），同期健康体检儿童52例为对照组，检测PCT及hs-CRP、WBC的水平并比较其与感染性疾病关系的差异。 结果细菌性感染组的PCT、WBC指标均显著高于对照组、病毒感染组（P＜0.01）；比较四组间的hs-CRP指标，差异均有统计学意义（P＜0.05）；细菌感染组阳性率PCT高于hs-CRP，差异有统计学意义（P＜0.05）；各组血清PCT与hs-CRP水平呈正相关（r=0.49，P＜0.05）。结论PCT与hs-CRP、WBC的联合监测可以提高儿童急性呼吸道感染早期诊断的准确率，根据结果判断呼吸道感染的严重程度，有助于儿童急性呼吸道感染疾病早期诊断、病情及预后的评估，值得临床推广。

血清降钙素原；超敏C反应蛋白；白细胞计数；儿童；急性呼吸道感染

［Abstract］Objective To investigate the c1inica1 va1ue of the serum proca1citonin（PCT）and hypersensitive C-reactive protein（hs-CRP）、WBC in the ear1y diagnosis of acute respiratory infections in chi1dren.Methods The c1inica1 data of 145 chi1dren diagnosed with acute respiratory infections in our hospita1 were co11ected（48 cases of bacteria1 infections group，39 cases of mycop1asma infections group，58 cases of virus infections group）.During the same period，52 hea1thy chi1dren were se1ected as contro1 group.The 1eve1s of serum PCT and hs-CRP，WBC shou1d be tested and the differences of the re1ationship with infectious diseases shou1d be compared.Results The indexes of PCT and WBC of the bacteria1 infections group were significant1y higher than those in contro1 group and virus infections group（P＜0.01）；hs-CRP indexes were compared among the four groups，the differences were significant（P＜0.05）；Bacteria1 infections group's positive rate in PCT was higher than that of hs-CRP，the difference was statistica11y significant（P＜0.05）；The serum PCT in each group was positive1y re1ated to the 1eve1 of hs-CRP（r=0.49，P＜0.05）.Conclusion The joint monitoring of PCT and hs-CRP、WBC can improve the accuracy of ear1y diagnosis of acute respiratory infections in chi1dren and judging the degree of the severity of respiratory infections according to the resu1ts wi11 contribute to the ear1y diagnosis，assesment of severity and prognosis of acute respiratory infections in chi1dren.It is worthy of c1inica1 promotion. ［Key words］Serum proca1citonin；Hypersensitive C-reactive protein；WBC；Chi1dren；Acute respiratory infections

儿童急性呼吸道感染是儿童最为常见的多发病，病原体多以细菌、病毒或混合感染为主，近年来发现支原体感染呈上升趋势。因患儿年龄原因多数不能准确描述病情，病原学检测困难且费时过长，而尽早判定病原体类型对患儿的早期诊断、临床治疗及预后均有重要意义。实验室检测对于感染性疾病的检测多采用血常规白细胞水平、PCT及CRP等［1］。……