于虹南宁市第一人民医院呼吸内科，广西南宁530021

广西鲍曼不动杆菌耐药性的地区差异

于虹
南宁市第一人民医院呼吸内科，广西南宁530021

目的探讨广西地区鲍曼不动杆菌耐药形势的地区差异性。方法对广西某大型三甲医院2014年临床标本分离出的1243株鲍曼不动杆菌对常用抗菌素的耐药率进行统计和分析。结果2014年除头胞哌酮/舒巴坦外，鲍曼不动杆菌对其他监测的抗菌药物耐药率均明显处于高水平，其中对氨曲南耐药率为100%，对哌拉西林及环丙沙星耐药率已接近90%，对碳青霉烯类药物（亚胺培南、美罗培南）耐药率已大于80%，并高于中国CHINET耐药监测数据。结论广西地区鲍曼不动杆菌耐药形势明显高于全国水平，具有地方差异性，应引起高度重视。

鲍曼不动杆菌；耐药性；CHINET；广西

［Abstract］Objective To study the reginal difference of drug resistance situation of acinetobacter baumanii in Guangxi. M ethods The drug resistance rate of 1243 strains of acinetobacter baumanii isolated from clinical specimens in some grade AAA hospital in Guangxi to common antibioticswas counted and analyzed.Results In addition to cefoperazone/sulbactam in 2014，the drug resistance rates of acinetobacter baumanii to the other antimicrobial drugs were obviously at a high level，among them，the resistance rate to aztreonam，piperacillin and ciprofloxacin and carbapenem（imipenem，meropenem）were respectively 100%，nearly 90%and more than 80%，which was higher than the drug resistancemonitoring data of China CHINET.Conclusion The drug situation of acinetobacter baumanii in Guangxiwas obviously higher than the national level with regional difference，which should be paid greatattention.

［Key words］Acinetobacter baumanii；Drug resistance；CHINET；Guangxi

不动杆菌属（Acinetobacter species）为一组基因相关的不发酵乳糖、氧化酶阴性的革兰氏阴性球杆菌。而鲍曼不动杆菌（Acinetobacter baumannii）是不动杆菌属中最具临床意义的一种，其中泛耐药鲍曼不动杆菌感染，尤其是碳青霉烯耐药鲍曼不动杆菌感染，是引起医疗成本及院内感染死亡率增高的重要原因［1-2］。2014年CHINET中国细菌耐药性监测结果显示：鲍曼不动杆菌对亚胺培南及美罗培南耐药率分别高达62.4%及66.7%，提示我国鲍曼不动杆菌耐药形势极为严峻［3］。了解广西地区鲍曼不动杆菌耐药情况，找出其地区差异性，对于指导广西地区鲍曼不动杆菌感染抗菌药物的经验性选择有重大意义。为此，该研究收集广西医科大学第一附属医院2014年临床标本分离的鲍曼不动杆菌菌株，对其耐药情况进行回顾性分析和总结，现报道如下。……