庞然然

奈达铂联合放疗治疗局部晚期宫颈癌的疗效与毒副反应观察

庞然然

【摘要】目的 探讨局部晚期宫颈癌患者采用奈达铂联合放疗治疗的疗效和毒副反应。方法 选取2012年1～12月本院收治的局部晚期宫颈癌患者68例，随机分为两组，各34例。对照组给予顺铂联合放疗治疗，观察组给予奈达铂联合放疗治疗，对比两组近期临床缓解率、3年生存率和毒副反应情况。结果 观察组近期临床缓解率、3年生存率与对照组相比，差异无统计学意义（P＞0.05）；观察组胃肠道反应和血小板降低发生率低于对照组，差异有统计学意义（P＜0.05）。结论 局部晚期宫颈癌患者采用奈达铂联合放疗治疗可减少毒副反应的发生。

【关键词】奈达铂；放疗；局部晚期宫颈癌；疗效；毒副反应

Objective To investigate the clinical effect and toxicity observation of nedaplatin combined with radiotherapy in treating locally advanced cervicalcancer. Methods 68 cases with advanced cervical cancer in our hospital from January 2012 to December 2012 were selected and divided into two groups，34 cases in each group. Control group was given cisplatinum combined with radiotherapy，observation group was given nedaplatin combined with radiotherapy. Compared the clinical remission rate，three-year survival rate，toxic and side effect of the two groups. Results Compared the clinical remission rate，three-year survival rate，toxic and side effect of the two groups，the difference was not statistically significant（P＞0.05）. Gastrointestinal reaction and incidence of thrombocytopenia of observation group were lower than control group，the difference was statistically significant（P＜ 0.05）. Conclusion Nedaplatin combined with radiotherapy in treating locally advanced cervical cancer can obviously improve clinical effect and reduce toxic and side effect.

【Key words】 Nedaplatin，Radiotherapy，Locally advanced cervical cancer，Clinical effect，Toxic and side effect

宫颈癌是一种发病率较高的妇科恶性肿瘤，在发病早期和中期运用手术治疗可起到效果，而在Ⅱb期以上的中晚期则需要给予放疗治疗，但单纯放疗对于未控及发生转移者无法起到效果［1］。相关文献报道［2］，运用放疗联合化疗可提高疗效。为进一步论证上述结论，在本研究中对我院收治的局部晚期宫颈癌患者给予奈达铂联合放疗治疗，对比顺铂联合放疗效果。报告如下。

1 资料与方法

1.1 一般资料

选取2012年1～12月本院收治的局部晚期宫颈癌患者68例，随机分为两组，各34例。对照组年龄为27～61岁，平均年龄为（47.7±4.2）岁；临床分期：Ⅱb期13例、Ⅲ期21例；肿瘤直径：＜4 cm者6例，≥4 cm者28例。观察组年龄为26～62岁，平均年龄为（48.1±4.5）岁；临床分期：Ⅱb期12例、Ⅲ期22例；肿瘤直径：＜4 cm者5例，≥4 cm者29例。……