牛晓霞 胡晓芸

[摘要] 目的 探讨氟哌噻吨美利曲辛片治疗慢性阻塞性肺疾病（COPD）加重期焦虑抑郁症的效果。 方法 选择我院2012年7月～2015年5月接收的106例COPD加重期焦虑抑郁症患者作为研究对象，按就诊先后顺序随机分为观察组与对照组。对照组53例患者接受常规治疗，观察组患者在对照组基础上接受氟哌噻吨美利曲辛片治疗。治疗1个月后，采用汉密尔顿焦虑、抑郁量表对患者进行评分，并比较两组的总体治疗效果。 结果 治疗后1个月，观察组的HAMA、HAMD评分显著低于照组，总有效率明显高于对照组，差异有统计学意义（P<0.05）。 结论 氟哌噻吨美利曲辛片治疗COPD加重期焦虑抑郁症的效果显著，可提高患者治疗依从性和生活质量。

[关键词] 慢性阻塞性肺疾病加重期；焦虑；抑郁；氟哌噻吨美利曲辛片

[中图分类号] R563.9 [文献标识码] A [文章编号] 1674-4721（2016）03（b）-0028-03

Effect observation of flupentixol and melitracen tablet treating exacerbation of chronic obstructive pulmonary disease aggravating with anxiety and depression

NIU Xiao-xia1 HU Xiao-yun2

1.Department of Internal Medicine，Lucheng People′s Hospital in Shanxi Province，Lucheng 047500，China；2.Department of Respiratory Medicine，the First Hospital Affiliated to Shanxi Medical University，Taiyuan 030001，China

[Abstract] Objective To explore the effect of flupentixol and melitracen tablet treating exacerbation of exacerbation of chronic obstructive pulmonary disease （COPD） aggravating with anxiety and depression. Methods 106 patients with exacerbation of COPD aggravating with anxiety and depression received by our hospital from June 2012 to May 2015 were selected as study object.Patients were randomly divided into observation group and control group according to the admit order.53 patients in control group were given routine treatment，while patients in observation group were given flupentixol and melitracen tablet on the basis of control group.After one month treatment，Hamilton anxiety and depression scale was used to score for patients and the total treatment effect between two groups was compared. Results After one month treatment， HAMA and HAMD score in observation group was obviously lower than that of control group respectively，and the total effective rate in observation group was obviously higher than that of control group，and there was a statistical difference （P<0.05）. Conclusion Flupentixol and melitracen tablet treating exacerbation of COPD aggravating with anxiety and depression has obvious effect，and it can improve the treatment compliance and life quality of patients.

[Key words] Exacerbation of chronic obstructive pulmonary disease；Anxiety；Depression；Flupentixol and melitracen tablet

慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）属于呼吸系统慢性疾病，病程持续时间较长且病情不断加重，致死率、致残率极高，严重影响患者的身心健康[1]。此外，COPD容易造成患者呼吸困难甚至衰竭，影响其精神状态，使其产生心理障碍，严重影响临床治疗效果[2]，因此，针对患者的心理障碍必须及时发现并治疗。氟哌噻吨美利曲辛片为一种复方制剂，其主要成分为盐酸氟哌噻吨和盐酸美利曲辛，临床上主要用于抗焦虑抑郁治疗[3]。氟哌噻吨美利曲辛片主要通过增加去甲肾上腺素、多巴胺等神经递质的含量来调节控制中枢神经系统，最终改善患者的精神状态，提高治疗依从性，使患者积极主动地配合治疗，促进临床工作的开展，帮助患者早日恢复健康[4]。本研究选择我院接收的106例COPD加重期焦虑抑郁症患者作为研究对象，对其中部分患者采用氟哌噻吨美利曲辛片治疗，效果较好。……