杨安宁 刘娟 班荣欣

[摘要] 目的 研究并探讨对黄体功能不全型先兆流产患者采用地屈孕酮与黄体酮治疗的临床效果。方法 依据纳入排除标准整群选取该院于2014年12月—2015年12月收治的先兆流产的患者102例作为研究对象，将其随机分两组，观察两组患者流产恢复情况和临床疗效。结果 研究组患者恢复正常时间短于对照组，且研究组采用地屈孕酮治疗后总有效为94.1%，对照组采用黄体酮的方式治疗后总有效为66.7%，组间比较差异有统计学意义。 结论 对于黄体功能不全型先兆流产患者采用地屈孕酮与黄体酮治疗可有效改善患者病情，对于患者预后恢复程度较好，故值得我们在临床上进行应用。

[关键词] 黄体功能不全；先兆流产；临床效果

[中图分类号] R714.21 [文献标识码] A [文章编号] 1674-0742（2016）03（c）-0112-02

Clinical Effect Observation on Dydrogesterone and Luteosterone in Treatment of Threatened Abortion Caused by Luteal Phase Defect

YANG An-ning1， LIU Juan1， BAN Rong-xin2

1. Pingdu Maternal and Child Health Care Hospital， Pingdu， Shandong Province， 266700 China；2.Affiliated Hospital of Qingdao University， Qingdao， Shandong Province， 266003 China

[Abstract] Objective To study and observe the clinical effect of dydrogesterone and luteosterone in treatment of threatened abortion caused by luteal phase defect. Methods 102 cases of patients from December 2014 to December 2015 with threatened abortion admitted and treated in our hospital were selected as the research object according to the inclusion and exclusion criteria and randomly divided into two groups， the recovery of abortion and clinical curative effects of the two groups were observed. Results The time returning to normal in the research group was shorter than that in the control group， the research group were treated with dydrogesterone and the total effective rate was 94.1%， the control group were treated with luteosterone and the effective rate was 66.7%， there was an obvious difference between groups by comparison with statistical significance. Conclusion Dydrogesterone and luteosterone in treatment of threatened abortion caused by luteal phase defect can effectively improve the patients condition， and the prognosis recovery degree of the patients is goos. Therefore， it is worth application in clinic.

[Key words] Luteal phase defect； Threatened abortion； Clinical effect

先兆流产是指产妇在妊娠28周之前，下体出现少量的阴道流血，从而出现阵发性下体疼痛，胎膜完整，无妊娠物排出，子宫大小与患者孕周相同。导致患者出现先兆流产的原因主要有染色体异常和母体因素，其中在母体因素中，患者黄体功能不全导致出现先兆流产的现象较多。在该研究中黄体功能不全主要是由于患者体内的黄体大于不够健全，患者体内孕激素分泌不足导致[1]。对于产妇而言，出现先兆流产这一状况，对患者无论是生理还是心理都受到了打击，对于患者预后有较大的影响，因此，对于先兆流产患者的治疗显得尤为重要，在该研究中整群选取2014年12月—2015年12月该院收治的102例患者为研究对象对采用黄体功能不全患者给予地屈孕酮与黄体酮进行治疗，以期为临床效果做出评价，现报道如下。……