马均

[摘要] 目的 探讨分析奥卡西平单药治疗儿童颞叶癫痫的临床疗效，为临床治疗儿童颞叶癫痫的治疗方案提供借鉴。方法 整群选取 2013年12月—2015年6月期间到该院儿科住院治疗的儿童颞叶癫痫患者144例，随机分为对照组（72例）和治疗组（72例），对照组给予丙戊酸钠治疗，治疗组给予奥卡西平治疗，比较治疗后两组患者临床治疗有效率、不良反应及癫痫发作频率等。 结果 治疗组的患者临床治疗有效率为83.33%，对照组为79.17%，整体上对照组患者不良反应发生率与治疗组差异无统计学意义，治疗6个月和12个月时对照组患者癫痫发作频率与治疗组相比差异无统计学意义，统计学处理后差异无统计学意义（P>0.05）。 结论 奥卡西平单药治疗儿童颞叶癫痫的临床疗效好，且不良反应发生率低，较安全，值得临床推广应用。

[关键词] 奥卡西平；儿童；颞叶癫痫；疗效分析

[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2016）03（c）-0106-02

Analysis of Clinical Curative Effect of Single Medicine？of Oxcarbazepine？in Treatment of Children Temporal Epilepsy

MA Jun

Department of Neurology， Changchun Children's Hospital， Changchun， Jilin Province， 130000 China

[Abstract] Objective To discuss and analyze the clinical curative effect of single medicine of oxcarbazepine in treatment of children temporal epilepsy to provide reference for the treatment plan of children temporal epilepsy in clinic. Methods 144 cases of children with temporal epilepsy treated in our hospital from December 2013 to June 2015 were selected and randomly divided into two groups with 72 cases in each， the control group were treated with sodium valproate， the treatment group were treated with oxcarbazepine， the clinical treatment effective rates， adverse reactions and frequencies of epilepsy seizures of the two groups after treatment were compared. Results The clinical treatment effective rate was 83.33% in the treatment group and 79.17% in the control group， overall， there was no obvious difference in the incidence rate between the control group and the treatment group， there was obvious difference in the frequency of epilepsy seizures after 6 months and 12 months of treatment between the control group and the treatment group， and the differences were not obvious after statistical treatment， P>0.05. Conclusion The clinical curative effect of single medicine？of oxcarbazepine？in treatment of children temporal epilepsy is good with low incidence rate of adverse reactions， and it is safe and is worth clinical promotion and application.

[Key words] Oxcarbazepine； Children； Temporal epilepsy； Analysis of curative effect

癫痫是脑内神经元放电异常所导致的短暂性脑功能障碍的一种阵发性疾病，发病多见于儿童和青少年，其中枕叶癫痫和颞叶癫痫是2种较为常见的发作类型[1]。癫痫临床发作症状复杂多样，主要有全面强直-阵挛性发作，以意识突然丧失、全身强直、抽搐为特征，大部分颞叶癫痫可用药物控制，一般采用奥卡西平治疗儿童颞叶癫痫疗效好、不良反应小，张瑞晓[2]报道奥卡西平不良反应较小，适合作为儿童癫痫治疗的一线药物。该研究整群选取2013年12月—2015年6月期间到该院住院治疗的儿童颞叶癫痫患者144例，对奥卡西平的临床疗效进行研究，现报道如下。