李晓波，郝占峰，杜　空，张叶芳(石家庄长城中西医结合医院周围血管科，河北 石家庄　050035)



马栗种子提取物联合复方紫草液治疗淤积性皮炎的疗效观察

李晓波*，郝占峰，杜空，张叶芳(石家庄长城中西医结合医院周围血管科，河北 石家庄050035)

DOI10.14009/j.issn.1672-2124.2016.03.027

摘要目的：探讨马栗种子提取物联合复方紫草液治疗淤积性皮炎的疗效。方法：选择2013年3月—2015年3月收治的120例淤积性皮炎患者作为研究对象，按随机数字表法分为观察组与对照组各60例。观察组患者给予马栗种子提取物联合复方紫草液外敷治疗，对照组患者给予马栗种子提取物加龙珠软膏外敷治疗，观察2组患者的疗效及症状、体征改善情况。结果：观察组患者的总有效率为95.00%(57/60)，对照组为78.33%(47/60)，2组的差异有统计学差异(P<0.05)。观察组患者治疗后症状积分为(4.20±1.20)分，对照组为(8.40±1.50)分，均明显优于治疗前的(18.90±2.40)、(19.10±2.60)分，且2组间比较，差异有统计学意义(P<0.05)。观察组患者的小腿周径差、皮炎面积为(1.88±0.57) cm、(4.96+1.51) cm2，对照组为(2.89±0.52) cm、(7.92+1.45) cm2，均较治疗前有明显减小，且2组间比较，差异有统计学意义(P<0.05)。结论：马栗种子提取物联合复方紫草液治疗淤积性皮炎效果较好，值得临床推广。

关键词淤积性皮炎； 马栗种子提取物； 复方紫草液

Observation on Efficacy of Extract of Horse Chestnut Seeds Tablets Combined with Compound Lithospermum Liquid in Treatment of Stasis Dermatitis

LI Xiaobo, HAO Zhanfeng, DU Kong, ZHANG Yefang(Dept.of Peripheral Vascular, Shijiazhuang Great Wall Hospital of Integrated Chinese and Western Medicine, Hebei Shijiazhuang 050035, China)

ABSTRACTOBJECTIVE：To probe into the clinical efficacy of extract of Horse chestnut seeds tablets combined with compound lithospermum liquid in treatment of stasis dermatitis. METHODS: 120 patients with stasis dermatitis admitted from Mar. 2013 to Mar. 2015 were selected to be divided into observation group and control group via the random number table, with 60 cases in each. The observation group were given extract of Horse chestnut seeds tablets combined with compound lithospermum liquid in external application, the control group received extract of Horse chestnut seeds tablets combined with dragon ball ointment in external application; the clinical efficacy, symptoms integral, margin of talocrural and stasis dermatitis area in two group of patients were observed. RESULTS: The total effective rate was 95.00%(57/60) in observation group and 78.33%(47/60)in control group, the difference was statistically significant(P<0.05). The symptoms integral was (4.20±1.20) in observation group and (8.40±1.50) in control group, both of which were significantly higher than that of before treatment (18.90±2.40) and (19.10±2.60), the difference was statistically significant between two groups(P<0.05). Meanwhile, the margin of talocrural and stasis dermatitis area in observation group were(1.88±0.57)cm and (4.96+1.51) cm2, and in control group were (2.89±0.52) cm and (7.92+1.45) cm2, both of which were significantly decreased compared with before treatment, the difference was statistically significant between two groups(P<0.05). CONCLUSIONS: Extract of Horse chestnut seeds tablets combined with compound lithospermum liquid in treatment of stasis dermatitis is effective, which is worthy of clinical promotion.

KEYWORDStasis dermatitis; Extract of Horse chestnut seeds tablets; Compound lithospermum liquid

淤积性皮炎又名坠积性皮炎、淤积性湿疹、低张力性皮炎、静脉曲张性湿疹[1]，是一种下肢慢性潮红、鳞屑、瘙痒和肿胀(炎症)的皮肤病，常有深褐色皮肤色素沉着。一般继发于静脉曲张、静脉血栓等静脉回流障碍疾病。本病病程迁延，治疗难度大，临床上常使用抗菌药物、抗组胺药、糖皮质激素等药物系统治疗，但效果不佳，且不良反应大。本研究探讨石家庄长城中西医结合医院(以下简称“我院”)采用复方紫草液联合马栗种子提取物治疗淤积性皮炎的疗效，现报告如下。

1资料与方法

1.1资料来源

选择2013年3月—2015年3月我院病房确诊为淤积性皮炎的患者120例作为研究对象，所有患者均符合《皮肤科治疗学》(2006年 1版)，淤积性皮炎的典型临床表现及体征[2]，并能按时复诊完成治疗。……