盛飞凤，赵晶晶，庄另发，陈小葵(广东省妇幼保健院药学部，广东 广州　511400)



广东省妇幼保健院门诊阴道炎处方分析

盛飞凤*，赵晶晶，庄另发，陈小葵#(广东省妇幼保健院药学部，广东 广州511400)

DOI10.14009/j.issn.1672-2124.2016.03.037

摘要目的：了解广东省妇幼保健院(以下简称“我院”)门诊阴道炎用药情况，促进临床合理用药。方法：对我院门诊7 935例阴道炎患者的处方进行分析,统计各种药物的使用率、限定日剂量、限定日费用、用药频度和药物利用指数。结果：药品使用率居前2位的是双唑泰栓和硝呋太尔-制霉菌素阴道栓，其限定日费用分别为4.14元和10.02元；抗菌药物用药频度居前3位的是克霉唑(19 151.60)、硝呋太尔(7 614.00)、甲硝唑(5 088.30)。结论：我院医师多选择双唑泰栓和硝呋太尔-制霉菌素阴道栓治疗阴道炎，此2种药物均为治疗混合感染的药物，用药存在不合理现象。

关键词阴道炎； 处方分析； 抗菌药物

Analysis on Outpatient Prescriptions of Vaginitis Medication in Guangdong Maternal and Child Health Hospital

SHENG Feifeng, ZHAO Jingjing， ZHUANG Lingfa， CHEN Xiaokui(Dept.of pharmacy, Guangdong Maternal and Child Health Hospital, Guangdong Guanzhou 511400, China)

ABSTRACTOBJECTIVE：To investigate the outpatient vaginitis medication in Guangdong Maternal and Child Health Hospital (hereinafter referred to as “our hospital”), and to promote the rational drug use in clinic. METHODS: 7 935 outpatient prescriptions of vaginitis medication were statistically analyzed in terms of the use rate, defined daily dose system(DDDs), defined daily cost(DDC), frequency of drug use and drug use index(DUI). RESULTS: The top two drug use rate were metronidazole clotrimazole and chlorhexidine acetate suppositories-nifuratel nysfungin suppository, with DDC of 4.14 and 10.02 yuan. The top three antibiotics ranked by frequency of drug use were respectively forclotrimazole (19 151.60), nifuratel (7 614.00) and metronidazole (5 088.30). CONCLUSIONS: Clinists in our hospital prefer to choose metronidazole clotrimazole and chlorhexidine acetate suppositories-nifuratel nystatin vaginal suppository in treatment of vaginitis, both of which were used for mixed infection. Meanwhile, there are still some irrational drug use phenomenon.

KEYWORDSVaginitis; Prescription analysis; Antibiotics

近年来我国妇科疾病普查报告显示，妇科疾病的发病率约为60%，炎症性疾病居妇科疾病的首位，其中阴道炎症排第1位，发病率仍呈上升趋势，发病年龄趋年轻化[1]。阴道炎可导致不孕和其他并发症，严重影响女性的生活质量[2]。阴道微生态群落中存在各种条件致病菌，如大肠杆菌、粪杆菌、加德纳菌、金黄色葡萄球菌、假丝酵母菌及支原体等，当阴道的微生态平衡被破坏时，条件致病菌是导致阴道炎的主要原因[3]。临床上常见的阴道炎一般有细菌性阴道炎、念珠菌性阴道炎、滴虫性阴道炎、老年性阴道炎[4]。各类阴道炎的治疗药物有时可共用，有时需区分使用，因此，容易产生不合理用药情况。……