黄玉斌，李赞东，曾诗婷(.广西壮族自治区南溪山医院药学部，广西 桂林　5400； .桂林医学院药学系，广西 桂林　5400)



2010—2014年广西壮族自治区南溪山医院呼吸科抗菌药物应用分析

黄玉斌1*，李赞东1，曾诗婷2(1.广西壮族自治区南溪山医院药学部，广西 桂林541002； 2.桂林医学院药学系，广西 桂林541002)

DOI10.14009/j.issn.1672-2124.2016.03.034

摘要目的：调查在抗菌药物专项整治活动前、后广西壮族自治区南溪山医院(以下简称“我院”)呼吸科住院患者抗菌药物的应用情况，为抗菌药物的临床合理用药提供参考。方法：对2010—2014年我院呼吸科住院患者抗菌药物合理使用情况、销售金额、用药频度(defined daily dose system,DDDs)等数据进行回顾性统计分析。结果：经过干预，抗菌药物合理使用情况得到改善，销售金额、住院人数虽然逐年升高，但DDDs、抗菌药物使用率呈下降趋势，我院抗菌药物DDDs由2010年82.6下降到2014年40.8，抗菌药物使用率由2010年93.3%下降到2014年77.3%。在合理使用情况中，联合用药率呈下降趋势，由2010年的69.9%下降为2014年的54.6%。标本送检率、治疗有效率逐年升高，标本送检率由2010年75.0%上升至2014年95.3%，治疗有效率由2010年80.3%上升至2014年89.7%。根据DDDs排位居前10位的抗菌药物提示，临床用药倾向于选择加酶抑制剂，或联合使用大环内酯类或氟喹诺酮类。结论：本次专项整治活动有助于促进我院抗菌药物的合理使用，呼吸科抗菌药物使用的合理性有了明显的提高，我院采取的干预措施有效、可行，但有待加大力度，不断规范化管理。

关键词呼吸科； 抗菌药物； 合理用药

Investigation on Application of Antibiotics in Department of Respiration in Guangxi Zhuang Autonomous Region Nanxishan Hospital during 2010-2014

HUANG Yubin1, LI Zandong1, ZENG Shiting2(1.Dept.of Pharmacy, Guangxi Zhuang Autonomous Region Nanxishan Hospital, Guangxi Guilin 541002, China; 2.School of Pharmacology, Guilin Medical University, Guangxi Guilin 541002, China)

ABSTRACTOBJECTIVE：To investigate the application status of antibiotics in department of respiration before and after special rectification in Guangxi Zhuang Autonomous Region Nanxishan Hospital (hereinafter referred to as “our hospital”), and to provide reference for the rational application of antibiotics in clinic. METHODS: The rational application status, data of the consumption sum, defined daily dose system(DDDs) of antibiotics in inpatients from department of respiration of certain a hospital during 2010-2014 were retrospectively statistically analyzed. RESULTS: After intervention, the rational application of antibiotics had been improved. Even through the consumption sum and hospitalized cases increased year by year, DDDs and use rate of antibiotics were in a decrease trend. Antibacterial drug DDDs down from 82.6 in 2010 to 40.8 in 2014,and the utilization rate dropped from 93.3% in 2010 to 77.3% in 2014. As for the rational application status, the drug combination rate dropped from 69.9% in 2010 to 54.6% in 2014 were but the specimen bacteria examination rate and effective rate of treatment increased year by year. According to the top 10 antibiotics ranked by DDDs, enzyme inhibitors were preferred in clinical drug use or in combination with macrolide or quinolone. CONCLUSIONS: The special rectification could promote the rational use of antibiotics， specimens were rate rose from 75.0% in 2010 to 95.3% in 2014 and efficient treatment, up from 80.3% in 2010 to 89.7% in 2014 and significantly increase the rationality of antibiotics in department of respiration. The intervention measures adopted by the hospital are effective and feasible, yet the standard management still needs to be strengthened.

KEYWORDSDepartment of respiration; Antibiotics; Rational drug use

抗菌药物在医院各科广泛应用，不合理使用诱导耐药菌株、甚至多重耐药菌株的出现，给临床治疗造成的困难也日益显著，全球每年因感染造成的死亡病例中85%以上由耐药菌株引起[1]。……