谭佳音(锦州市妇婴医院消化神经科，辽宁 锦州　121000)



奥卡西平和左乙拉西坦单药治疗伴中央颞区棘波的儿童良性癫痫的疗效比较

谭佳音*(锦州市妇婴医院消化神经科，辽宁 锦州121000)

DOI10.14009/j.issn.1672-2124.2016.03.025

摘要目的：比较奥卡西平和左乙拉西坦单药治疗伴中央颞区棘波的儿童良性癫痫的疗效。方法：选择锦州市妇婴医院2012年1月—2014年12月收治的108例伴中央颞区棘波的良性癫痫患儿作为研究对象，按随机数字表法分为观察组和对照组各54例，对照组患儿口服奥卡西平治疗，观察组患儿口服左乙拉西坦治疗，比较患儿的疗效与不良反应。结果:对照组患者的总有效率为79.63%(43/54)，观察组为87.04%(47/54)，观察组患儿的总有效率略高于对照组，但差异无统计学意义(P>0.05)；观察组患儿的不良反应发生率为为5.56%(3/54)，对照组为27.78%(15/54)，2组的差异有统计学意义(P<0.05)。结论：奥卡西平和左乙拉西坦治疗伴中央颞区棘波的儿童良性癫痫疗效相当，左乙拉西坦的不良反应发生率明显低于奥卡西平。

关键词良性癫痫； 奥卡西平； 左乙拉西坦； 儿童

Comparison on Efficacy of Oxcarbazepine and Levetiracetam Monotherapy in Treatment of Benign Epilepsy Children with Centro-temporal Spikes

TAN Jiayin(Dept.of Digestive Nerve Section, the Maternal and Children Hospital of Jinzhou, Liaoning Jinzhou 121000, China)

ABSTRACTOBJECTIVE：To compare the efficacy of oxcarbazepine and levetiracetam monotherapy in treatment of benign epilepsy children with centro-temporal spikes. METHODS: 108 benign epilepsy children with centro-temporal spikes admitted into the Maternal and Children Hospital of Jinzhou from Jan. 2012 to Dec. 2014 were selected to be divided into observation group and control group via the random number table, with 54 cases in each. The control group were treated with oral oxcarbazepine, the observation group received oral levetiracetam; the efficacy and adverse drug reactions were compared between two groups. RESULTS: The total effective rate of observation group was 87.03%(47/54), significantly higher than that of control group 79.63%(43/54), with no statistically significant difference(P>0.05). The incidence of adverse drug reactions of the observation group was 5.56%(3/54), and the control group was 27.78%(15/54), with statistically significant difference (P<0.05). CONCLUSIONS: The efficacy of oxcarbazepine and levetiracetam monotherapy in treatment of benign epilepsy children with centro-temporal spikes are equivalent, yet the incidence of adverse drug reactions of levetiracetam is significantly lower than that of oxcarbazepine.

KEYWORDSBenign epilepsy; Oxcarbazepine; Levetiracetam

伴中央颞区棘波的儿童良性癫痫(benign epilepsy in childhood,BECT)是一种最常见的儿童良性部分性癫痫，大约占小儿癫痫15%～20%[1]。因致痫灶放电本身对大脑是种损伤，影响患儿身心发育，所以对频繁发作(一年内发作次数≥2次)、发病年龄小、日间部分性发作及继发性全身发作者，需进行药物治疗[2]。奥卡西平、左乙拉西坦是目前临床使用较广泛的抗癲痫药[3]，本研究采用随机对照方法，观察以上两种药物的临床疗效及不良反应，现报告如下。

1资料与方法

1.1资料来源

选取2012年1月—2014年12月在锦州市妇婴医院确诊为BECT的108例患儿作为研究对象。诊断和分类依据国际抗癫痫联盟关于癫痫和癫痫综合征的分类标准[4]，入组标准：(1)年龄6～11岁；(2……