徐高峰(麻城市人民医院心内科，湖北 麻城　438300)



琥珀酸美托洛尔缓释片和酒石酸美托洛尔片治疗慢性收缩性左心功能衰竭的疗效比较

徐高峰*(麻城市人民医院心内科，湖北 麻城438300)

DOI10.14009/j.issn.1672-2124.2016.03.021

摘要目的: 研究琥珀酸美托洛尔与酒石酸美托洛尔治疗左心功能枯竭为慢性收缩性的疗效和安全性。方法：选从麻城市人民医院2009年5月—2013年8月收治的左心功能枯竭为慢性收缩性的患者190例作为研究对象，按照随机数字表法将患者分为观察组和对照组，每组各95例。观察组患者选取琥铂酸美托洛尔进行治疗，对照组患者则选取酒石酸美托洛尔片进行治疗。结果：观察组患者总有效率为96.8%(92/95)，明显高于对照组87.4%(83/95),差异有统计学意义(P<0.05)。观察组患者左心室射血分数改善情况优于对照组，且心功能和平均中位心力衰竭缓解时间均高于对照组，差异均有统计学意义(P<0.05)。但2组患者的不良反应比较，差异无统计学意义(P>0.05)。结论：与酒石酸美托洛尔比较，琥珀酸美托洛尔治疗慢性收缩性左心功能衰竭疗效较好，安全性较高，值得临床推广。

关键词慢性收缩性左心功能衰竭； 酒石酸美托洛尔； 琥铂酸美托洛尔

Observation on Efficacy of Metoprolol Succinate Sustained-release Tablets and Metoprolol Tartrate Tablets in Treatment of Flat Systolic Chronic Left Heart Failure

XU Gaofeng(Dept.of Cardiology，Macheng Municipal People’s Hospital，Hubei Macheng 438300，China)

ABSTRACTOBJECTIVE：To research the curative effects and safety of Metoprolol succinate sustained-release tablets and Metoprolol tartrate tablets in treatment of flat systolic chronic left heart failure. METHODS: 190 cases with flat systolic chronic left heart failure admitted into Macheng Municipal People’s Hospital from May 2009 to August 2013 were selected to be divided into observation group and control group via the random number table，with 95 cases in each. The observation group were treated with Metoprolol succinate sustained-release tablets，and the control group received Metoprolol tartrate tablets. RESULTS: The total effective rate of observation group was 96.8%(92/95),which was significantly higher than that of the control group 87.4%(83/95)，there were statistically significant differences between two groups(P<0.05).The left ventricular enjection fraction(LVEF)，cardiac function and the average remission duration of medium heart failure in observation group were better than that in control group，with statistically significant difference(P<0.05). There was no significant of adverse drug reactions between two group of patients(P>0.05). CONCLUSIONS:Compared with metoprolol tartrate, metoprolol succinate in the treatment of chronic systolic of left heart function failure curative effect better, higher security, it is worth clinical promotion.

KEYWORDSChronic systolic left ventricular failure； Metoprolol tartrate tablets； Metoprolol succinate sustained-release tablets

慢性收缩性左心功能衰竭为临床常见病和多发病[1]。对于患有此类疾病的患者，当下医学已从单一的更正血液的流动性混乱改变为制止神经的内分泌，逆袭心肌的重构医治时代，β1受体的阻断药剂使用最为重要也特别广泛，但由于该药物使用剂量和剂型不恰当，不但无法改良患者的心力衰竭，反而可能导致心力衰竭加重[2],因此，应用时应特别注意。本研究对麻城市人民医院(以下简称“我院”)收治的190例慢性收缩性左心功能衰竭患者的临床资料进行分析，并比较琥珀酸美托洛尔和酒石酸美托洛尔的疗效，现报告如下。……