余　超(汉川市人民医院儿科，湖北 汉川　431600)



布地奈德联合盐酸氨溴索雾化吸入治疗小儿支气管肺炎的疗效观察

余超*(汉川市人民医院儿科，湖北 汉川431600)

DOI10.14009/j.issn.1672-2124.2016.03.020

摘要目的:探讨布地奈德配合盐酸氨溴索实行雾化吸入治疗支气管肺炎患儿的临床疗效。方法：选择汉川市人民医院2013年2月—2015年1月期间收治的188例支气管炎患儿作为研究对象，按随机数字表法分为观察组与对照组，每组各94例。对照组患儿使用布地奈德气雾剂对患儿实行雾化治疗，观察组患儿在对照组的根本上配合盐酸氨溴索雾化吸入。观察2组患儿的总有效率、症状消失与住院时间。结果：通过治疗，观察组患儿的总有效率为96.81%(91/94)，显著高于对照组的87.23%(82/94)，差异有统计学意义(P<0.05)；观察组患儿症状消失与住院的时间显著低于对照组，差异有统计学意义(P<0.01)。2组患儿不良反应发生情况比较，差异有统计学意义(P<0.05)。结论：使用布地奈德配合盐酸氨溴索药物对患有支气管肺炎的患儿实行雾化吸入，效果理想，可缩短治疗的时间，安全可靠，值得临床推广。

关键词雾化吸入； 布地奈德； 盐酸氨溴索； 小儿支气管炎

Observation on Efficacy of Budesonide Combined with Ambroxol Hydrochloride Inhalation in Treatment of Children with Bronchial Pneumonia

YU Chao(Dept.of Pediatrics，Hanchuan People’s Hospital，Hubei Hanchuan 431600，China)

ABSTRACTOBJECTIVE：To probe into the clinical efficacy of budesonide combined with ambroxol hydrochloride inhalation in treatment of children with bronchial pneumonia. METHODS: 188 cases of children with bronchial pneumonia admitted into Hanchuan People’s Hospital from Feb. 2013 to Jan. 2015 were selected to be divided into observation group and control group via the random number table，with 94 cases in each. The control group were treated with the budesonide aerosol，while the control group additionally received ambroxol hydrochloride inhalation based on the control group. The total effective rate，disappearance time of symptoms and length of stay in two group of patients were observed and compared. RESULTS: After treatment，the total effective rate of of observation group was 96.81%(91/94)，significantly higher than that of control group 87.23%(82/94)，with statistically significant difference(P<0.05). Yet the disappearance time of symptoms and length of stay in observation group was significantly lower than that in control group，the difference was extremely significant(P<0.01). There were statistically significant differences of adverse drug reactions between two group of patients(P<0.05). CONCLUSIONS: Not only the efficacy of budesonide combined with ambroxol hydrochloride inhalation in treatment of children with bronchial pneumonia is significant， but can shorten the treatment time，with safe and reliable effects. It is worthy of clinical application and promotion.

KEYWORDSAtomization inhalation； Budesonide； Ambroxol hydrochloride； Children with bronchial pneumonia

支气管肺炎在婴幼儿当中最为常见，患病的常为0.5～1岁的婴幼儿[1]。临床的主要变现为低氧血症、咳嗽、肺部啰音与憋喘时气急，在憋喘严重时还会合并心力、呼吸衰竭等，患儿有着较为明显的毛细管堵塞状况[2]。本研究对汉川市人民医院(以下简称“我院”)2013年2月—2015年1月期间收治94例患儿进行布地奈德配合盐酸氨溴索雾化吸入治疗，取得了较好的疗效，现报告如下。

1资料与方法

1.1资料来源

本次研究的188例患儿中，男性111例，女性77例，年龄0.5～1岁，平均年龄(3.20±1.50)岁，病程2～10 d，平均(3.60±1.30) d。2组患儿年龄、性别、病程等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。本研究经医院医学伦理委员会批准，患者及家属均签署了知情同意书。