OCT定量检测对糖尿病白内障患者视网膜神经纤维厚度的价值

2016-04-25方廷兵李惠英

国际眼科杂志 2016年4期

关键词：老年

方廷兵，严　浩，李惠英

作者单位：(518052)中国广东省深圳市第六人民医院眼科

·临床研究·

OCT定量检测对糖尿病白内障患者视网膜神经纤维厚度的价值

方廷兵，严浩，李惠英

作者单位：(518052)中国广东省深圳市第六人民医院眼科

Clinical application of OCT to detect retinal nerve fiber layer thickness in senile cataract patients

Ting-Bing Fang, Hao Yan，Hui-Ying Li

Department of Ophthalmology, the Sixth People’s Hospital of Shenzhen，Shenzhen 518052, Guangdong Province，China

Correspondence to:Hao Yan. Department of Ophthalmology, the Sixth People’s Hospital of Shenzhen，Shenzhen 518052,Guangdong Province，China. yanhaoe@163.com

Received：2015-12-22Accepted：2016-03-17

Abstract

•AIM: To apply optical coherence tomography (OCT) in the detection of retinal nerve fiber layer (RNFL) thickness in senile cataract patients and to analyze the changes of RNFL and the correlation with the patient’s visual acuity after phacoemulsification.

•METHODS: Fifty-one senile cataract patients (70 eyes) received the phacoemulsification. The patients were divided into diabetes mellitus (DM) group and non-DM group. There were 30 cases (38 eyes) in non-DM group and 21 cases (32 eyes) in DM group. After treatments, OCT was applied to detect the patients’ RNFL thickness at different time periods (at 3, 14d, 1, 3 and 6mo after treatments). At different time periods, RNFL thickness was detected to analyze its correlation with the best corrected visual acuity (BCVA).

•RESULTS: At 3 and 14d after treatments, RNFL thickness of non-DM group was not different from that of DM group (P>0.05); at 3 and 6mo after treatments, RNFL thickness of non-DM group was smaller than that of DM group (P<0.05); the uncorrected visual acuity of the two groups before treatments had no statistical significant differences compared with those at 3,14d and 1mo postoperatively(P>0.05); the uncorrected visual acuity of DM group at 3, 6mo postoperatively was significantly lower than those of non-DM group(P<0.05); at 14d, 1 and 3mo after treatments, the RNFL thickness of non-DM group was negatively correlated with the patient’s visual acuity (P<0.05); at 14d, 1, 3 and 6mo after treatments, RNFL thickness of DM group was negatively correlated with the patient’s visual acuity (P<0.05).

•CONCLUSION: OCT is a good detecting parameter for the change of RNFL thickness and the change of RNFL thickness is an important cause of the changes of the patient’s visual acuity.

KEYWORDS:•optical coherence tomography; senile; cataract; phacoemulsification; retinal nerve fiber layer thickness

Citation:Fang TB, Yan H, Li HY.Clinical application of OCT to detect retinal nerve fiber layer thickness in senile cataract patients.GuojiYankeZazhi(IntEyeSci) 2016;16(4):709-711

摘要

关键词：光学相干断层扫描仪；老年；白内障；超声乳化吸除术；视网膜神经纤维层厚度

引用：方廷兵，严浩，李惠英.OCT定量检测对糖尿病白内障患者视网膜神经纤维厚度的价值.国际眼科杂志2016;16(4):709-711

0引言

白内障是临床上较为常见的一种眼科疾病，本病在老年人群中的发病率较高[1]。手术是目前临床上治疗白内表1两组患者术后不同时间盘周RNFL厚度比较障较为有效的一种手段，随着临床研究的深入，白内障超声乳化吸除联合人工晶状体植入术成为治疗本病技术成熟且效果较好的一种术式[2]。该手术在乳化吸出晶状体核的同时，对周围组织也会导致一定程度的损伤[3]。以往研究的关注点更多的放在角膜及黄斑这些可以早期严重影响视功能的组织上，但是白内障施行超声乳化吸出术后视神经损伤方面的观察研究很少[4]。为进一步探讨光学相干断层扫描仪(optical coherence tomography，OCT)定量检测老年白内障患者视网膜神经纤维层(retinal nerve fiber layer，RNFL)厚度的变化，分析老年白内障患者实施超声乳化吸除手术后盘周RNFL的变化特点以及与视力的相关性，我们对我院收治的51例手术病例进行了临床分组观察，现报告如下。