陈志雄，付劲松，宋　薇，王晨秀，章玉玲

作者单位：1(330006)中国江西省南昌市，江西省人民医院内分泌科；2(330006)中国江西省南昌市，江西省眼科中心 江西省人民医院眼科



·临床研究·

雷珠单抗联合激光光凝治疗糖尿病性黄斑水肿的效果分析

陈志雄1，付劲松2，宋薇1，王晨秀1，章玉玲1

作者单位：1(330006)中国江西省南昌市，江西省人民医院内分泌科；2(330006)中国江西省南昌市，江西省眼科中心 江西省人民医院眼科

Effect analysis of Ranibizumab with laser photocoagulation therapy for diabetic macular edema

Zhi-Xiong Chen1, Jin-Song Fu2, Wei Song1, Chen-Xiu Wang1, Yu-Ling Zhang1

1Department of Endocrinology, Jiangxi Provincial People’s Hospital, Nanchang 330006, Jiangxi Province, China;2Department of Ophthalmology, Jiangxi Provincial People’s Hospital, Jiangxi Eye Center, Nanchang 330006, Jiangxi Province, China

Correspondence to:Jin-Song Fu. Department of Ophthalmology, Jiangxi Provincial People’s Hospital, Jiangxi Eye Center, Nanchang 330006, Jiangxi Province, China. fzyfzy999@sina.com

Received：2016-01-08Accepted：2016-03-17

Abstract

•AIM: To analysis the clinical effect of Ranibizumab with laser photocoagulation for diabetic macular edema.

•METHODS: Forty-two cases (72 eyes) of patients with diabetic macular edema collected from April 2014 to June 2015 in our hospital were randomly divided into observation group and control group. The observation group was given ranibizumab with laser photocoagulation therapy, and the control group was only given laser photocoagulation treatment. Macular edema subsiding, macular fovea retinal thickness change and vision improvement were compared between the two groups.

•RESULTS: The total effective rate of the observation group was 94%, that of the control group was 78%, and the difference between the two groups was statistically significant (P<0.05). Before the treatment, macular foveal retinal thickness of the observation group was 486.58±85.26μm, that of the control group was 479.61±83.37μm, and the difference between the two groups was not statistically significant (P>0.05). At 3mo after treatments, the macular fovea retinal thickness of the observation group was 315.85±43.7μm that of the control group was 418.85±46.97μm. At 6mo after treatments, the macular fovea retinal thickness of the observation group and the control group was 245.58±25.67 and 369.85±36.48μm respectively, and the difference between the two groups was statistically significant (P<0.05). The vision improvement rates of the observation group and the control group were 78% and 50% respectively, and the difference between the two groups was statistically significant (P<0.05).

•CONCLUSION: The treatment effect of ranibizumab with laser photocoagulation therapy for diabetic macular edema is remarkable, and recommended in clinical promotion.

KEYWORDS:•diabetic macular edema; ranibizumab; laser photocoagulation; vision

Citation:Chen ZX, Fu JS, Song W,etal. Effect analysis of Ranibizumab with laser photocoagulation therapy for diabetic macular edema.GuojiYankeZazhi(IntEyeSci) 2016;16(4):706-708

摘要

关键词：糖尿病性黄斑水肿；雷珠单抗；激光光凝；视力

引用：陈志雄，付劲松，宋薇，等.雷珠单抗联合激光光凝治疗糖尿病性黄斑水肿的效果分析.国际眼科杂志2016;16(4):706-708

0引言

糖尿病性黄斑水肿属于糖尿病常见并发症之一，主要是由于糖尿病因素引起的一种视网膜微血管病变，患者血管通透性增加造成细胞外液积聚、渗漏，导致视网膜增厚或硬性渗出现象，对患者视力影响极大[1]。本文主要对比分析抗VEGF药物联合激光光凝治疗与单独采用激光光凝治疗糖尿病性黄斑水肿患者的临床疗效，现总结分析如下。

1对象和方法

1.1对象收集2014-04/2015-06我院收治的42例72眼糖尿病黄斑水肿患者为研究对象，将患者随机分为观察组21例36眼与对照组21例36眼。观察组男11例19眼，女10例17眼，年龄48～78(平均60.25±3.25)岁，糖尿病平均病程9.57±2.11a。对照组男12例20眼，女9例16眼，年龄47～77(平均60.46±3.19)岁，糖尿病平均病程9.63±2.09a。本次所有研究患者均接受眼底镜和眼底荧光素血管造影(FFA)证实，排除近期内接受糖皮质激素药物治疗者、老年性黄斑变性者、中心性浆液性视网膜病变者及合并恶性肿瘤患者。……