刘亚芬　李秀玲　孙莉　赵丽华

[摘要] 目的 观察益气补肾活血方对老年糖尿病轻度认知功能障碍患者认知能力的影响。 方法 选取我院2015年3～9月老年糖尿病轻度认知功能障碍患者70例，将其随机分为益气补肾活血方治疗组（治疗组）与空白对照组（对照组），各35例，继续对两组原有疾病进行常规治疗，治疗组在常规治疗基础上给予益气补肾活血方配方颗粒口服。经过12周的治疗后，采用简易智能状态量表（MMSE）、临床痴呆评定量表（CDR），日常生活能力量表（ADL）分别测定两组患者。 结果 治疗组显效率（37.1%）高于对照组（14.3%），总有效率（82.8%）明显高于对照组（45.7%），差异有统计学意义（P<0.05）；治疗组MMSE及ADL评分均优于对照组（P<0.05）。 结论 益气补肾活血方可改善老年糖尿病轻度认知功能障碍患者的认知能力，提高其生活质量。

[关键词] 益气补肾活血方；糖尿病；老年；轻度认知功能障碍

[中图分类号] R277.7 [文献标识码] A [文章编号] 1674-4721（2016）02（c）-0100-03

[Abstract] Objective To observe the impact of Yiqi bushen huoxue decoction on cognitive ability of elderly diabetes patients with mild cognitive impairment. Methods 70 elderly diabetes patients with mild cognitive impairment from March to September 2015 of our hospital were selected.Patients were randomly divided into Yiqi bushen huoxue decoction treatment group（treatment group） and control group，and each group was 35 cases.The primary diseases were treated with general treatment sustained.Patients in treatment group were treated with Yiqi bushen huoxue decoction on the basis of general treatment.After treatment for 12 weeks，the MMSE，CDR and ADL between two groups were tested. Results The obvious effective rate of treatment group was 37.1%，higher than that was 14.3% in control group；The total effective rate was 82.8% in treatment group，obvious higher than that was 45.7% in control group，and the difference was statistical significance（P<0.05）.The MMSE and ADL in treatment group was better than that of control group respectively（P<0.05）. Conclusion Yiqi Bushen Huoxue decoction can improve cognitive ability of elderly diabetes patients with mild cognitive impairment and life quality.

[Key words] Yiqi bushen huoxue decoction；Diabetes；Elderly；Mild cognitive impairment

随着人口老龄化的到来，我国糖尿病患病率已达9.7%，其中男性和女性糖尿病的患病率分别达10.6%和8.8%[1]。老年糖尿病患者越来越多，老年糖尿病轻度认知功能障碍（mild cognitive impairment，MCI）的发病率也逐年增高。研究表明，糖尿病是阿尔次海默病的独立危险因素[2]；糖尿病患者MCI发病率高[3]。有研究发现[4]，糖尿病组所有类型痴呆的发生率均显著高于正常组。流行病学研究表明，老年糖尿病患者发生痴呆的危险性较正常对照组增高2倍[5]。近年研究结果表明，糖尿病患者存在MCI，将严重影响到患者的生活质量及其治疗方案的实施[6]。部分老年糖尿病MCI患者病情逐年加重，通常是由于忘记吃药或忘记注射胰岛素等，导致血糖升高，甚至出现大血管、微血管并发症，出现认知功能下降。……