补肾方药对老年高血压病肾气亏虚证患者性激素相关调控因子的干预作用

于杰1,张磊2,郭伟星3*

(1.山东中医药大学，济南 250355；2.山东中医药大学附属医院，济南 250014；

3.山东省医学科学院，济南 250000)

摘要：目的对老年高血压病肾气亏虚证患者经益肾降压方干预前后性激素相关调控因素水平进行比较。方法根据高血压病诊断与分级标准，老年高血压病肾气亏虚证量化诊断标准，选择老年高血压病肾气亏虚证患者60例，男女各半，给予益肾降压方治疗4周，采用酶联免疫吸附法检测白介素-2(IL-2)、瘦素(Leptin)、促性腺激素释放激素(GnRH)和硫酸脱氢表雄酮(DHEA-S)的水平。结果经益肾降压方干预后男性老年高血压病肾气亏虚证患者的血清Leptin和GnRH的水平有所回落,DHEA-S的水平有所回升，女性老年高血压病肾气亏虚证患者血清GnRH的水平有所回落。结论补肾方药在男性性激素相关调控因素水平上的作用靶点可能为瘦素、促性腺激素释放激素和硫酸脱氢表雄酮，女性可能为促性腺激素释放激素。

关键词：老年人;高血压病;肾气亏虚证;补肾方药;性激素;调控因子

DOI::10.13463/j.cnki.jlzyy.2015.07.012

中图分类号：R544.1文献标志码： A

文章编号：1003-5699(2015)07-0687-03

基金项目:国家自然科学

作者简介:于杰(1980-)，女，硕士研究生，讲师，主要从事中医药治疗心血管系统疾病的研究。

收稿日期:(责任编辑：张晔2014-10-28)

*通信作者:郭伟星，教授，电话-13573143915,电子信箱-k361@163.com

Effect of kidney tonifying prescription intervention the level of sex hormones related

regulating factors of elderly hypertension kidney-qi deficiency syndrome

YU Jie1,ZHANG Lei2,GUO Weixing3*

(1.Shandong University of Traditional Chinese Medicine,Jinan 250355,China;

2.The Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China;

3.Shandong Provincial Academy of Medical Sciences,Jinan 250000,China)

Abstract:ObjectiveThis paper studies the effect of kidney tonifying prescription intervention the level of sex hormones related regulating factors of elderly hypertension kidney-qi deficiency syndrome.MethodsAccording to hypertension diagnosis and classification standard，TCM differentiation standard chose elder hypertension of kidney deficiency syndrome (60 cases),half of men and women,give kidney tonifying prescription for 4 weeks.The Elisa method was used to detect IL-2，Leptin，GnRH and DHEA-S levels.ResultsAfter kidney tonifying prescription intervention,the levels of Leptin and GnRH of elderly male patients with hypertension of kidney-qi deficiency syndrome declined,the levels of DHEA-S increased.The levels of GnRH of elderly female patients with hypertension of kidney-qi deficiency syndrome declined.ConclusionThe target of kidney tonifying prescription on sex hormones related regulating factors of elderly male patients may be Leptin,GnRH and DHEA-S.The target of kidney tonifying prescription on sex hormones related regulating factors of elderly female patients may be GnRH.

Keywords:elder;hypertension;kidney deficiency syndrome;kidney tonifying prescription;sex hormones;regulating factors

老年高血压病作为高血压病中的一个特殊类型，与青、中年人群的高血压病相比，具有患病率高，血压波动大，易产生体位性低血压，并发症多而严重，病死率高等特有的临床特点。……