周亮++王世明

[摘要] 原发性肝癌已成为五大恶性肿瘤之一，是导致肿瘤患者死亡的第三大因素。在我国，原发性肝癌更是极为常见的恶性肿瘤之一，死亡率较高，仅次于胃癌、食管癌。一直以来，原发性肝癌诊断是临床上的重点、难点，最近几年，临床上对原发性肝癌的研究取得了显著的进步，治疗方法已从单一外科治疗发展到外科治疗为主、局部治疗为辅、多学科的综合治疗，因此早期发现原发性肝癌对提高临床治疗有效率具有极其重要的作用，尤其是新技术、新方法的出现，明显改善了原发性肝癌的临床诊断和治疗效果，极大地提高了我国原发性肝癌患者的生存率及生活质量。

[关键词] 原发性肝癌；早期诊断；GP73；AFP异质体；发展历程

[中图分类号] R735.7 [文献标识码] A [文章编号] 1674-4721（2015）02（a）-0015-03

Application progress of joint detection of GP73，AFP corpora heterogenium in early diagnosis of primary liver cancer

ZHOU Liang WANG Shi-ming

Department of General Surgery，The First Clinical Medical College of Shanxi Medical University，Taiyuan 030001，China

[Abstract] Primary liver cancer （PHC） has become one of the five malignant tumors，is the third major factor leading to the death of patients with cancer.In China，PHC is one of the extremely common malignant tumors with a higher mortality rate，and the mortality rate is next only to gastric cancer，esophageal cancer.All the time since，the diagnosis of PHC is the focus and difficulty in clinical medicine，in recent years，the clinical research on PHC has made significant progress，the treatment method has been developed from the single surgical treatment to the multi-disciplinary comprehensive treatment of surgical treatment mainly，local treatment auxiliarily，therefore early detection of PHC has extremely important role for improving the effective rate of clinical treatment，especially the emergence of new technologies and new methods significantly improve the clinical diagnosis and treatment of PHC，which greatly improve the survival rate and quality of life in patients with PHC in China.

[Key words] Primary liver cancer；Early diagnosis；GP73；AFP corpora heterogenium；Development history

源自肝细胞和肝内胆管上皮细胞的恶性肿瘤被称为原发性肝癌[1]（以下简称肝癌），以肝细胞癌和肝内胆管细胞癌最为常见，其中肝细胞癌所占比例高达90%以上，因此通常情况下，肝癌指的就是肝细胞癌。在我国，乙肝病毒感染是引发肝癌的主要病因，丙肝病毒感染及长时期饮酒为次要病因[2]，肝癌起病隐匿，发展却很迅速，当患者被确诊为肝癌时多已经转移或发生远处转移，生存期较短[3]，因此早期诊断肝癌对治疗肝癌及确保患者长期生存具有至关重要的作用[4]。甲胎蛋白（alpha fetal protein，AFP）被认为是目前诊断肝癌和预后的首选标志物，其诊断肝癌的灵敏度为50%～60%[5]，将有一部分被漏诊，所以，就目前提高对肝癌的早期诊断率的高尔基体蛋白73（GP73）联合AFP检测进行综述[6]。……