阿托伐他汀联合低分子肝素治疗COPD急性加重期30例临床疗效观察
2015-01-21熊家义
熊家义
【摘要】目的:探讨阿托伐他汀联合低分子肝素治疗COPD急性加重期的临床疗效。方法:观察60例肺源性心脏病患者为研究对象,随机将其分为实验组和对照组,每组30例。对照组患者采用阿托伐他汀进行治疗;实验组患者采用阿托伐他汀联合低分子肝素进行治疗。6周为一疗程,疗程结束后,比较两组患者的临床疗效。结果:疗程结束以后,两组患者的症状都有所改善,实验组患者的总有效率为786%,明显高于对照组患者的562%,差异具有统计学意义(P<005)。结论:阿托伐他汀联合低分子肝素治疗COPD急性加重期,可以明显提高患者的临床疗效,改善患者的生活质量,临床应用值得推广。
【关键词】阿托伐他汀;低分子肝素;疗效观察
【中图分类号】R563【文献标志码】 A【文章编号】1007-8517(2014)12-0059-02
Abstract:Objective To investigate the atorvastatin clinical efficacy of LMWH treatment of acute exacerbation of COPD.Methods observation 60 cases of pulmonary heart disease patients in our hospital were randomly divided into experimental and control groups, every group has 30 cases,the control group were treated with atorvastatin treatment in the experimental group were treated with atropine atorvastatin treatment with low molecular weight heparin.6 weeks for a course after the end of treatment, the clinical efficacy of the two groups of patients.The results after the end of treatment, both groups of patients with symptoms have improved, the total effective rate of patients in the experimental group was 786%,significantly higher than 56.2% of the patients, and (P<005), the difference was statistically significant.Conclusion Atorvastatin treatment with low molecular weight heparin in acute exacerbation of COPD, can significantly improve the clinical efficacy of patients, improve the quality of life of patients, worthy of clinical application.
Keywords:atorvastatin; low molecular weight heparin; Efficacy
COPD即为慢性阻塞性肺病,是老年慢性支气管炎、哮喘患者常见的合并症,属气流受限的可以预防和治疗的疾病类型。本病气流受限呈持续性、进行性加重,是气道炎症性疾病。COPD急性加重期的死亡率极高,约为11%[1],是呼吸内科常见的急症,如不能及时治疗,会严重威胁患者的生命。在慢性肺源性心脏病死亡患者的尸检报告中发现,899%的患者由细小动脉血栓形成[2]。因此,笔者认为有必要在治疗COPD急性加重期时,在常规用药的基础上,加用低分子肝素抗凝治疗。笔者应用阿托他汀联合低分子肝素治疗COPD急性重期30例,取得满意疗效,具体报道如下。
1资料和方法
11一般资料选取2013年1月至2014年1月我院收治的60例肺源性心脏病患者为研究对象,60例患者均符合中华医学会呼吸学会2007年制定的《慢性阻塞性肺疾病诊治指南)(2007年修订版)的诊断标准[1]。将所有患者随机分为实验组和对照组,每组各30例。……
