齐俊佳++徐长水

[摘要] 目的 探讨参芪花粉片联合β受体阻滞剂治疗血管迷走性晕厥与单用β受体阻滞剂疗效的比较。 方法 将96例确诊为血管迷走性晕厥的患者随机分为2组，对照组患者服用琥珀酸美托洛尔缓释片，47.5mg/次，1 次/d，实验组加用参芪花粉片3.75g/次，2次/d。治疗前及治疗3个月后分别进行直立倾斜试验，同时观察患者晕厥复发情况。 结果 实验组有效率为85.4%，对照组有效率为70.8%（P<0.05）。两组治疗前后平均血压差值均数比较治疗组小于对照组（P<0.05），平均心率比较治疗组小于对照组（P>0.05）。 结论 参芪花粉片联合β受体阻滞剂治疗血管迷走性晕厥的疗效明显优于单用β受体阻滞剂，且有稳定血压作用，药物安全性也更高。

[关键词]参芪花粉片；β-受体；受体阻滞剂；琥珀酸美托洛尔；血管迷走性晕厥；直立倾斜试验

[中图分类号] R364.14 [文献标识码] B [文章编号] 2095-0616（2014）16-67-04

Clinical observation of Shenqi pollen plates combined with beta adrenergic antagonists in treatment of vasovagal syncope

QI Junjia XU Changshui

Department of Neurology， Henan People's Hospital， Zhengzhou 450003， China

[Abstract] Objective To observe the clinical effect of Shenqi pollen plates combined with beta adrenergic antagonists in treatment of vasovagal syncope. Methods 96 vasovagal syncope patients in our hospital were randomly divided into two groups， which were treatment group and control group. Two groups were given metoprolol succinate extended release tablets 47.5mg orally， once a day， additionally， treatment group was given Shenqi pollen plates 3.75g orally， twice a day， and were followed up for 3 months. Head-up tilt testing was performed before treatment and reviewed three months later， moreover， recording the recurrence of syncope. Results The therapeutic efficiency ratio of treatment group was 85.4%，while the control group was 70.8%（P<0.05）.Before and after treatment， means of blood pressure difference in treatment group was less than control group（P<0.05）， means of heart rate difference in treatment group was less than control group（P>0.05）. Conclusion The therapeutic efficiency of Shenqi pollen plates combined with beta adrenergic antagonists is better than taking beta adrenergic antagonists alone， blood pressure can be more stable， safety can be higher.

[Key words] Shenqi pollen plates；β-receptor； Receptor antagonists； Metoprolol succinate；Vasovagal syncope； Head-up tilt testing

血管迷走性晕厥（vasovagal syncope，VVS）是多种诱因导致迷走神经过度兴奋而引起脑灌注不足，短暂的意识丧失，患者反复晕厥发作严重影响生活质量及生命健康，针对VVS治疗方法的研究为该疾病的研究热点之一，国内外学者做了很多药物及非药物治疗的试验，但至今仍没有明确有效的治疗方法[1-2]。参芪花粉片为祖国中药制剂，临床工作中治疗VVS在使用β受体阻滞剂的基础上加用参芪花粉片治疗，发现比常规治疗方法有更好疗效，目前有关参芪花粉片治疗VVS的研究国内外尚无报道。因此，我们设计了一个随机对照实验，探讨参芪花粉片联合β受体阻滞剂对血管迷走性晕厥的治疗效果，现报道如下。

1 资料与方法

1.1 一般资料

本研究病例为符合入组标准的2010年1月～2013年9月期间本院门诊及住院患者，共96例。……