齐桂杰+王丽红

[摘要] 目的 分析克拉霉素联合奥美拉唑治疗慢性胃炎的临床效果和安全性，探讨其临床适用性。 方法 选择2012年3月～2013年10月本院收治的67例慢性胃炎患者，随机分为观察组35例和对照组32例，对照组给予奥美拉唑治疗，观察组在此基础上联合克拉霉素治疗，观察两组的总有效率及不良反应情况。 结果 观察组的总有效率为94.28%，对照组的总有效率为75.00%，差异有统计学意义（χ2=4.8965，P=0.0269）。观察组的不良反应发生率为11.43%，对照组的不良反应发生率为12.50%，差异无统计学意义（χ2=0.0183，P=0.8925）。 结论 克拉霉素联合奥美拉唑治疗慢性胃炎安全有效，值得临床推广应用。

[关键词] 克拉霉素；奥美拉唑；慢性胃炎

[中图分类号] R573.3[文献标识码] A[文章编号] 1674-4721（2014）05（c）-0082-03

The efficacy and safety analysis of clarithromycin in the treatment of chronic gastritis

QI Gui-jie1 WANG Li-hong2

1.Department of Gastroenterology,Jinxi Petrochemical Hospital in Liaoning Province,Huludao 121000,China;2.Department of Endoscopy,Suizhong Hospital of Liaoning Province,Suizhong 121000,China

[Abstract] Objective To analyze the efficacy and safety of clarithromycin in the treatment of chronic gastritis in order to explore its clinical applicability. Methods 67 cases of patients with chronic gastritis from March 2012 to October 2013 in our hospital were selected and randomly divided into observation group(35 cases)and control group(32 cases),omeprazole was used in control group,on the basis of omeprazole therapy,clarithromycin was used in observation group.Total effective rate and adverse reaction in two groups was observed respectively. Results Total effective rate in observation group was 94.28%,total effective rate in control group was 75.00%,with statistical difference(χ2=4.8965,P=0.0269).The incidence rate of adverse reaction in observation group was 11.43%,the incidence rate of adverse reaction in control group was 12.50%,with no statistical difference(χ2=0.0183,P=0.8925). Conclusion Clarithromycin combined with omeprazole in the treatment of chronic gastritis is safe and effective,it is worthy of clinical promotion and application.

[Key words] Clarithromycin;Omeprazole;Chronic gastritis

慢性胃炎是临床上非常普遍的慢性胃黏膜疾病[1]，发病原因不明，与幽门螺杆菌感染关系密切，患者长期胃部不适，偶伴有恶心、呕吐、嗳气等症状，严重影响患者的生活质量。奥美拉唑是治疗慢性胃炎的常用药物，可以较好地改善患者的胃部不适症状，临床上应用比较广泛，疗效显著[2]。对于伴有幽门螺杆菌感染的患者，通常采用联合其他抗生素进行综合治疗[3]。本院近期研究奥美拉唑联合克拉霉素治疗慢性胃炎患者的临床效果和安全性。

1 资料与方法

1.1 一般资料

选择2012年3月～2013年10月本院收治的67例慢性胃炎患者，排除伴有其他重要脏器严重疾病患者，根据治疗方式不同，随机分为观察组和对照组。观察组35例，男11例，女24例；年龄25～55岁，平均为（38.2±6.8）岁；病程3个月～2年，平均（5.7±3.3）个月，尿素呼气试验检查：Hp阴性患者14例，Hp阳性患者21例。……