郭新生 易士华

[摘要] 目的 探讨氯吡格雷联合阿司匹林在短暂性脑缺血发作中的疗效及安全性。 方法 选取60例TIA患者，随机分为两组，对照组予小剂量阿司匹林，观察组则在对照组予氯比格雷，比较两组的疗效及用药安全性。 结果 观察组总有效率达90.0%，与对照组的总有效率73.3%比较，差异有统计学意义（P＜0.05）。观察组治疗后发作时间均较治疗前及对照组缩短更明显，差异有统计学意义（P＜0.05）。 结论 氯吡格雷联合阿司匹林治疗短暂性脑缺血发作能明显减少发作时间，改善患者的临床症状，安全性好，值得推广和应用。

[关键词] 短暂性脑缺血发作；氯吡格雷；阿司匹林

[中图分类号] R743.31???[文献标识码] B???[文章编号] 2095-0616（2012）15-73-02

Efficacy and safety of clopidogrel andaspirin treatment of transient ischemic attack

GUO?Xinsheng??YI?Shihua

Department of Internal Medicine,Suichuan County People's Hospital,Suichuan 343900,China

[Abstract] Objective To explore efficacy and security of clopidogrel and aspirin in transient ischemic attack. Methods 60 patients with TIA were randomly divided into two groups,the low-dose aspirin inthe control group. On thebase of the control group,observation group were givenclopidogrel,the efficacy and drug safety were comparedbetween the two groups. Results Total effective rateof the observation group was 90%,total effective rate of the control group was 73.3%,the difference was significant (P＜0.05). The onset time compared with treatment groups after treatment was significantly shorter in the observation group and the control group,and the observation group reducedthe more obvious.The difference was significant (P＜0.05). Conclusion Clopidogrel and aspirin treatment of transient ischemic attack is good and the clinical efficacy is superior than aspirin alone treatment.

[Key words] Transient ischemic attack;Clopidogrel;Aspirin

短暂性脑缺血发作（transient ischemic attack，TIA）是指颈动脉或椎-基底动脉系统短暂性供血不足，导致脑供血突然出现一过性局灶性神经功能障碍[1]。如不及时治疗，约有25％～43％的患者2～3年内将产生严重的缺血性脑血管病[2]。本研究旨在探讨氯吡格雷联合阿司匹林在短暂性脑缺血发作中的疗效及安全性，现报道如下。

1?资料与方法

1.1?一般资料

2009年1月～2012年1月，选择笔者所在医院住院治疗的TIA患者进行观察， 符合全国第四届脑血管病会议提出的标准，全部入选患者随机分为观察组和对照组各30例，观察组男12例，女18例，年龄55～75岁，平均（55.8±2.1）岁，病变位于颈内动脉系统19例，椎-基底动脉系统11例。其中伴高血压9例，冠心病2例，高脂血症11例、糖尿病8例。对照组男11例，女19例，年龄52～70岁，平均（56.9±1.8）岁，病变位于颈内动脉系统20例，椎-基底动脉系统10例。……