[摘要]目的：探讨非剥脱性1 565 nm点阵激光联合强脉冲光对面颈部皮肤光老化就医者皮肤状态的影响。方法：选取2022年6月-2023年5月笔者医院收治的90例皮肤光老化的就医者，按照抽签法将就医者分为对照组和观察组，各45例。对照组给予强脉冲光治疗，观察组在对照组治疗基础上予以非剥脱性1 565 nm点阵激光治疗，两组就医者均治疗5次。比较两组治疗效果、治疗前后就医者皮肤症状（包括皮肤松弛、毛孔粗大、毛细血管扩张、色素沉着）、皮肤屏障功能指标皮肤表面pH值、角质层含水量、经皮水分丢失（TEWL），并统计两组就医者治疗满意度。结果：观察组治疗效果优于对照组（P＜0.05）。治疗后，两组各皮肤症状评分与治疗前相比均下降（P＜0.05），且观察组上述症状评分均低于对照组（P＜0.05）。治疗后，两组TEWL均较治疗前减小（P＜0.05），角质层含水量均较治疗前增大（P＜0.05），观察组皮肤表面pH值减小（P＜0.05），对照组皮肤表面pH值变化差异无统计学意义（P＞0.05），且组间比较观察组TEWL均小于对照组（P＜0.05），角质层含水量高于对照组（P＜0.05）。观察组不良反应发生率与对照组差异无统计学意义（P＞0.05）。观察组就医者满意度高于对照组（P＜0.05）。结论：非剥脱性1 565 nm点阵激光联合强脉冲光可以更好地改善面颈部皮肤光老化就医者皮肤状态，提高其满意度。

[关键词]非剥脱性1 565 nm点阵激光；强脉冲光；皮肤光老化；皮肤状态

[中图分类号]R616.4" " [文献标志码]A" " [文章编号]1008-6455（2025）06-0119-04

Influence of Non-Ablative 1565 nm Fractional Laser Combined with Intense Pulsed Light on" Face And Neck Skin Photoaging Condition

GENG Yaqiong1， CHEN Xiaohui1， TIAN Wei1， WANG Xianlu1， CAO Dongsheng2

（ 1.Department of Aesthetic Surgery，Taihe County People's Hospital， Taihe Hospital Attached to Wannan Medical College， Fuyang 236600， Anhui， China; 2. Department of Plastic and Aesthetic Surgery， the Second Affiliated Hospital of Anhui Medical University， Hefei 230031， Anhui， China）

Abstract： Objective" To investigate the influence of non-ablative 1565 nm fractional laser combined with intense pulsed light on skin condition in patients with skin photoaging. Methods" 90 patients with skin photoaging in the hospital were selected from June 2022 to May 2023， and were classified into control group （45 cases） and observation group （45 cases） by adopting the lottery method. The control group carried out intense pulsed light， whereas the observation group received non-ablative 1 565 nm fractional laser on the basis of treatment in the control group. Both groups were treated 5 times. The therapeutic effect as well as skin symptoms （including skin relaxation， coarse pores， telangiectasia， pigmentation） and skin barrier function indexes [skin surface pH value， stratum corneum water content， transepidermal water loss （TEWL）] before and after treatment were compared between groups， and the treatment satisfaction was counted in both groups. Results" The observation group had better therapeutic effect （P＜0.05）. After treatment， the skin symptoms scores in both groups were decreased compared with those before treatment （P＜0.05）， and the above scores were lower in the observation group （P＜0.05）. The TEWL in the two groups after treatment was reduced compared with that before treatment （P＜0.05） while the water content of stratum corneum was enhanced （P＜0.05）， and the pH value of skin surface in the observation group was declined （P＜0.05）， and there was no statistical significance in the change of skin surface pH value in the control group （P＞0.05）. The TEWL in the observation group was lower （P＜0.05） while the water content of stratum corneum was higher compared to the control group （P＜0.05）. The incidence rates of adverse reactions in the observation group were not statistically different from those in the control group （P＞0.05）.The observation group had higher satisfaction （P＜0.05）. Conclusion" Non-ablative 1565 nm fractional laser combined with intense pulsed light can improve the skin condition and enhance the satisfaction in patients with skin photoaging.

Key words：" non-ablative 1 565 nm fractional laser; intense pulsed light; skin photoaging; skin condition

皮肤老化分为自然老化和外源性老化，前者为遗传和不可抗拒的因素引起，如地心引力、机体自然衰退等；后者是外界环境导致，如紫外线、烟尘、有害化学物质等[1-2]。……