[摘要]目的：分析甲泼尼龙对肿块型肉芽肿性乳腺炎术后乳房美学与康复效果的改善作用。方法：根据治疗方案将2021年1月-2023年1月笔者科室收治的97例肿块型肉芽肿性乳腺炎患者分为对照组（n=49）和激素组（n=48）。对照组行乳腺病变组织扩大切除术治疗，激素组在乳腺病变组织扩大切除术的基础上给予甲泼尼龙治疗，两组均随访1年。比较两组术后疼痛情况、并发症、疗效、血清炎症指标、术后1年乳房美学效果及患者满意度。结果：激素组切口愈合时间、住院时间均短于对照组（P＜0.05）；术后3个月，激素组总有效率高于对照组（P＜0.05）；术后7、14 d激素组VAS评分低于对照组（P＜0.05）；术后8周，激素组血清IL-6、CRP、IL-2水平低于对照组（P＜0.05）；术后1年，激素组乳房美学效果优良率和患者满意度高于对照组（P＜0.05）。结论：乳腺病变组织扩大切除术后应用甲泼尼龙可促进肿块型肉芽肿性乳腺炎患者术后康复、抑制炎症指标异常，进而有助于改善疗效及预后情况，巩固乳房美学效果，获得患者认可，安全性良好。

[关键词]肿块型肉芽肿性乳腺炎；甲泼尼龙；康复；预后；美学效果

[中图分类号]R622" " [文献标志码]A" " [文章编号]1008-6455（2025）06-0048-04

Effect of Methylprednone on Breast Aesthetics and Rehabilitation after Mastitis with Lump-type Granulomatous Disease

SUO Pengfeng， BAI Yanhua， ZHANG Yiying

（ Department of Breast Surgery， Zhangjiakou First Hospital， Zhangjiakou 075000， Hebei， China ）

Abstract： Objective" To analyze the effect of methylprednone on breast aesthetics and rehabilitation after mastitis with lump-type granulomatous disease. Methods" 97 patients with mass granulomatous mastitis admitted to the author's hospital from January 2021 to January 2023 were divided into the non-hormone group （n=49） and the hormone therapy group （n=48） by the treatment plan. The non-hormone group was treated with enlarged resection of breast lesions， while the hormone treatment group was treated with methylprednone on the basis of enlarged resection of breast lesions. Both groups were followed up for 1 year. The prognosis and postoperative rehabilitation of the two groups were compared 3 months after surgery， pain 1， 7 and 14 d after surgery， serum inflammation indicators before and 8 weeks after surgery， cosmetic effect of breast 1 year after surgery， recurrence and complications during follow-up. Results" The incision healing time and hospital stay in the hormone group were shorter than those in the control group （P＜0.05）. At 3 months after operation， the total effective rate of the hormone group was higher than that of the control group （P＜0.05）. The VAS scores of the hormone group were lower than those of the control group at 7 and 14 days after operation （P＜0.05）. At 8 weeks after operation， the serum levels of IL-6， CRP and IL-2 in hormone group were lower than those in control group （P＜0.05）. One year after operation， the excellent rate of breast aesthetic effect and patient satisfaction in hormone group were higher than those in control group （P＜0.05）. Conclusion" The application of methylprednone after enlarged resection of breast lesions could promote the postoperative rehabilitation of patients with lump-granulomatous mastitis， inhibit the abnormal inflammatory indicators， and then help to improve the curative effect and prognosis， consolidate the cosmetic effect of breast， gain patient approval， with good safety.

Key words： mass granulomatous mastitis; methylprednisolone; rehabilitation; prognosis; aesthetic effect

肿块型肉芽肿性乳腺炎具体发病原因不明，为慢性乳腺炎症性疾病，病理可检出乳腺小叶和导管周围的非干酪样肉芽肿[1]。肿块型肉芽肿性乳腺炎治疗过程复杂、病情容易复发、迁延难愈，如进展至溃破期则需行手术治疗。乳腺病变组织扩大切除术为肿块型肉芽肿性乳腺炎的常见手术治疗方案，可切除病灶，清洁组织，改善疾病进展，但术后复发率高[2-3]。……