贺鹏志 宁峰

【摘要】 目的：分析肝硬化门静脉高压相关并发症发生的危险因素。方法：回顾性分析2020年1月—2023年1月郴州市第二人民医院收治的322例肝硬化门静脉高压患者的临床资料，统计其并发症发生情况，另收集患者的年龄、性别等资料，统计分析并发症发生的危险因素。结果：322例肝硬化门静脉高压患者中，发生并发症的有58例，发生率为18.01%（58/322）。单因素分析显示，发生组的肝功能Child-Pugh分级为C级占比、有红色征占比均高于未发生组，门静脉内径高于未发生组，PT长于未发生组，ALB低于未发生组，差异均有统计学意义（P<0.05）。logistic回归分析显示，肝功能Child-Pugh分级为C级[OR=8.566，95%CI（4.535，16.181）]、有红色征[OR=10.817，95%CI（5.490，21.316）]、门静脉内径高[OR=1.791，95%CI（1.430，2.244）]、PT延长[OR=1.804，95%CI（1.496，2.176）]为肝硬化门静脉高压并发症发生的危险因素，ALB水平[OR=0.912，95%CI（0.852，0.977）]为肝硬化门静脉高压并发症发生的保护因素（P<0.05）。结论：肝功能Child-Pugh分级为C级、有红色征、门静脉内径高、PT延长为肝硬化门静脉高压并发症发生的危险因素，ALB水平高为肝硬化门静脉高压并发症发生的保护因素。

【关键词】 肝硬化门静脉高压 并发症 危险因素

Risk Factors Analysis of Complications Related to Portal Hypertension in Liver Cirrhosis/HE Pengzhi， NING Feng. //Medical Innovation of China， 2024， 21（14）： -159

[Abstract] Objective： To analyze the risk factors for complications related to portal hypertension in liver cirrhosis. Method： A retrospective analysis was conducted on the clinical data of 322 patients with portal hypertension in liver cirrhosis admitted to Chenzhou City NO.2 People's Hospital from January 2020 to January 2023， the incidence of complications was statisticed， and data such as age and gender were collected， the risk factors for incidence of complications were statistically analyzed. Result： Among the 322 patients with portal hypertension in liver cirrhosis， 58 had complications， incidence rate of 18.01% （58/322）. Univariate analysis showed that proportion of Child-Pugh grade C liver function， proportion of red signs in the incidence group were higher than those in the non incidence group， portal vein diameter was higher than that in the non incidence group， PT was longer than that in the non incidence group， and ALB was lower than that in the non incidence group （P<0.05）. logistic regression analysis shows that the Child Pugh grading of liver function as grade C [OR=8.566， 95%CI （4.535， 16.181）]， with red sign [OR=10.817， 95%CI （5.490， 21.316）]， high portal vein diameter [OR=1.791， 95%CI （1.430， 2.244）]， PT extension [OR=1.804， 95%CI （1.496， 2.176）] were risk factors for complications of portal hypertension in liver cirrhosis， high ALB level [OR=0.912， 95%CI （0.852， 0.977）] was protective factors for the occurrence of complications of liver cirrhosis with portal hypertension （P<0.05）. Conclusion： The Child-Pugh grading of liver function as grade C， with red signs， high portal vein diameter， and prolonged PT are risk factors for the occurrence of complications of portal hypertension in liver cirrhosis， high ALB level is protective factor for the occurrence of complications of portal hypertension in liver cirrhosis.

[Key words] Portal hypertension in liver cirrhosis Complications Risk factors

First-author's address： Hepatology Department 1， Chenzhou City NO.2 People's Hospital， Chenzhou 423000， China

doi：10.3969/j.issn.1674-4985.2024.14.037

肝硬化门静脉高压为临床常见病，是一组以门静脉压力上升和血流动力学异常为主要特点且涉及全身多脏器、多系统的综合病症[1-2]。此类患者的病情较为复杂，且较易诱发一系列并发症，如肝性脑病、食管-胃底静脉曲张等[3-4]。并发症如若发生，将会导致患者住院时间延长，增加其经济压力，还会加重其原本病情，影响预后。由于此类患者的有关并发症比较繁多，故并发症发生的危险因素亦具有多样性，临床并未完全明晰[5-6]。因此，及时了解肝硬化门静脉高压相关并发症发生的独立危险因素，指导临床施以针对性的防治措施，对于保证患者身心健康具有重要意义。基于此，本研究分析肝硬化门静脉高压相关并发症发生的危险因素，现报道如下。

1 资料与方法

1.1 一般资料

回顾性分析2020年1月—2023年1月郴州市第二人民医院收治的322例肝硬化门静脉高压患者的临床资料。……