刘则鹏 张玉洁

*基金项目：武威市科技计划项目（WW2101177）

【摘要】 目的：探讨栀豉温胆汤联合荆花胃康胶丸对反流性食管炎（RE）患者症状改善情况及炎症因子水平的影响。方法：用随机数字表法将2022年9月—2023年9月在武威市凉州医院就诊的100例RE患者分成两组，观察组、对照组，各50例。对照组予予雷贝拉唑治疗，在上述治疗上，观察组予栀豉温胆汤联合荆花胃康胶丸治疗。对比两组症状改善情况、炎症因子水平、血清胃动素（MTL）与胃泌素（GAS）水平。结果：治疗后，两组反流性疾病问卷（RDQ）总积分均较治疗前降低，且观察组RDQ总积分更低，差异均有统计学意义（P<0.05）。治疗后，两组白介素（IL）-17、IL-6与肿瘤坏死因子-α（TNF-α）均较治疗前下降，且观察组IL-6、IL-17与TNF-α均较对照组低，差异均有统计学意义（P<0.05）。治疗后，两组MTL与GAS均较治疗前升高，且观察组MTL与GAS均较对照组高，差异均有统计学意义（P<0.05）。结论：栀豉温胆汤联合荆花胃康胶丸治疗RE可减轻炎症反应，调节血清MTL与GAS水平，改善临床症状。

【关键词】 反流性食管炎 栀豉温胆汤 荆花胃康胶丸 炎症因子

Effect of Zhichi Wendan Decoction Combined with Jinghua Weikang Capsules on the Improvement of Symptoms and Levels of Inflammatory Factors in Patients with Reflux Esophagitis/LIU Zepeng， ZHANG Yujie. //Medical Innovation of China， 2024， 21（14）： 0-043

[Abstract] Objective： To explore the effect of Zhichi Wendan Decoction combined with Jinghua Weikang Capsules on the improvement of symptoms and the level of inflammatory factors in patients with reflux esophagitis （RE）. Method： A total of 100 RE patients who received treatment at Liangzhou Hospital in Wuwei City from September 2022 to September 2023 were divided into two groups by random number table method， the observation group and the control group， with 50 cases in each group. The control group was treated with Rabeprazole， while the observation group was treated with Zhichi Wendan Decoction combined with Jinghua Weikang Capsules. The improvement of symptoms， levels of inflammatory factors， serum motilin （MTL） and gastrin （GAS） levels were compared between the two groups. Result： After treatment， the total score of the reflux disease questionnaire （RDQ） in both groups were decreased compared to those before treatment， and the total score of RDQ in the observation group was lower than that in the control group， the differences were statistically significant （P<0.05）. After treatment， interleukin （IL）-17， IL-6， and tumor necrosis factor-α （TNF-α） in two groups were decreased compared to those before treatment， and IL-6， IL-17， and TNF-α in the observation group were decreased compared with the control group， the differences were statistically significant （P<0.05）. After treatment， MTL and GAS in both groups were increased compared to those before treatment， MTL and GAS in the observation group were higher compared with the control group， the differences were statistically significant （P<0.05）. Conclusion： The combination of Zhichi Wendan Decoction and Jinghua Weikang Capsules can alleviate inflammation， regulate serum MTL and GAS levels， and improve clinical symptoms in the treatment of RE.

[Key words] Reflux esophagitis Zhichi Wendan Decoction Jinghua Weikang Capsules Inflammatory factor

First-author's address： National Medical Museum， Liangzhou Hospital in Wuwei City， Wuwei 733000， China

doi：10.3969/j.issn.1674-4985.2024.14.010

反流性食管炎（RE）为消化科常见病，症状以上腹灼烧感、胸痛、反流等最为常见，若治疗不及时还可出现吞咽困难、腹胀等症，影响患者精神情志和生活质量[1]。现阶段临床治疗RE多用药物干预，常用的有促胃动力药、质子泵抑制剂等，虽能一定程度改善RE病症，但难以根治疾病，治疗效果不佳[2-3]。随着中医药事业的快速发展，近年在RE治疗中积累了大量的临床经验，依据其临床表现，中医将RE归为“食管瘅”“嘈杂”等范畴，病位在食管、胃，与肝胆脾关系密切，多因饮食不节、情志不畅等影响中焦气机升降，致胃气上逆、胃失和降所致，治疗当注重降逆和胃、开郁化痰、健脾理气[4]。荆花胃康胶丸、栀豉温胆汤均为治疗胃肠疾病常用药，前者有化痰清热、散寒理气、健脾之功[5]，后者有清热解毒、降逆和胃、化痰等功效。……