王海燕

【摘 要】目的：探讨血清CRP、CA19-9与CEA联合检测在结直肠癌术前诊断中的应用作用。方法：选择我院在2020年1月—2020年12月收治的80例结直肠癌患者，在患者入院后尽快为其进行血清CRP、CEA和CA19-9的联合检测，对比这些患者的术后病理结果探讨各指标检测对结直肠癌患者术前诊断的应用价值。结果：应用血清CRP、CA19-9和CEA对不同结直肠癌患者病理TNM分期、T分期、M分期均有显著统计学意义（P<0.05），且对应的ROC曲线下AZ值均有差异（P<0.05）。最终发现联合应用血清CRP、CA19-9以及CEA检测结直肠癌患者与病理金标准对比准确率达到96.2%，明显高于单一使用血清CRP、CA19-9和CEA的检测准确率。结论：结合患者血清CRP、CA19-9以及CEA指标对结直肠癌患者进行联合检测，对其术前病理分期的评估有一定的价值，可辅助诊断患者的病情，用于临床参考。

【关键词】血清CRP；CA19-9；CEA；联合检测；结直肠癌；术前诊断

Application of combined detection of serum CRP， CA19-9 and CEA in preoperative diagnosis of colorectal cancer

Wang Haiyan

Department of laboratory， Anning District People’s Hospital， Lanzhou Gansu 730070， China

【Abstract】Objective： To investigate the application of serum CRP， CA19-9 and CEA in the preoperative diagnosis of colorectal cancer. Methods： 80 patients with colorectal cancer treated in our hospital from January 2020 to December 2020 were selected. The combined detection of serum CRP， CEA and CA19-9 was carried out as soon as possible after admission. The postoperative pathological results of these patients were compared to explore the application value of each index in the preoperative diagnosis of colorectal cancer patients. Results： Serum CRP， CA19-9 and CEA had significant statistical significance in pathological TNM stage， T stage and M stage of different colorectal cancer patients（P < 0.05）， and the AZ value under the corresponding ROC curve was different （P < 0.05）. Finally， it was found that the accuracy of combined application of serum CRP， CA19-9 and CEA in the detection of colorectal cancer patients was 96.2%， which was significantly higher than that of single use of serum CRP， CA19-9 and CEA. Conclusion： the combined detection of serum CRP， CA19-9 and CEA in patients with colorectal cancer has a certain value in the evaluation of preoperative pathological stage， which can assist in the diagnosis of patients’ condition and be used for clinical reference.

【Key？Words】serum CRP； CA19-9； CEA； Joint testing； Colorectal cancer； Preoperative diagnosis

當前，在各种恶性肿瘤的发病与病死统计中，结直肠癌分别位列第三和第四位，严重威胁了患者的生命安全。多年的研究实践证实[1]，尽早为患者进行诊断和干预，可显著改善其预后。而CA19-9糖链抗原19-9、CEA血清癌胚抗原都属于检测结直肠癌疾病的肿瘤标志物，在为患者诊断和确诊上有着重要意义。另外CRP C-反应蛋白也发挥了越来越重要的作用，临床认为该指标可作为结直肠癌患者术前诊断的新指标。为了探讨这些指标用于结直肠癌患者术前诊断的价值，本研究选入80例已病理确诊的结直肠癌患者，对比其相关指标的检测结果，现分析报告如下。

1.1 一般资料