廖汉杰，吴建武，阮金德

【摘要】目的分析支原体肺炎患儿通气功能障碍发生的影响因素。方法回顾性分析深圳市宝安区石岩人民医院2018年10月至2020年10月收治的80例支原体肺炎患儿临床资料，所有患儿均行肺功能检测，将发生通气功能障碍患儿纳入发生组，未发生通气功能障碍患儿纳入未发生组。统计所有患儿临床资料，分析支原体肺炎患儿通气功能障碍发生的影响因素。结果纳入的80例支原体肺炎患儿中，发生通气功能障碍18例，发生率为22.50%;初步比较两组一般资料后，将符合条件的变量分别纳入，经logistic回归分析显示，发热时间长及C反应蛋白（CRP）、降钙素原（PCT）、单核细胞趋化蛋白（MCP）-1过表达是支原体肺炎患儿发生通气功能障碍的影响因素（OR>1，P<0.05）。结论支原体肺炎患儿通气功能障碍发生风险较高，发热时间长及CRP、PCT、MCP-1过表达是支原体肺炎患儿发生通气功能障碍的影响因素。

【关键词】支原体肺炎;通气功能障碍;发热时间;C反应蛋白;降钙素原;单核细胞趋化蛋白-1

中图分类号：R725.6文献标志码：ADOI：10.3969/j.issn.1003-1383.2021.11.011

Influencing factors of ventilation dysfunction in children with mycoplasma pneumonia

LIAO Hanjie， WU Jianwu， RUAN Jinde

（Department of Pediatrics， Shiyan People's Hospital of Bao'an District， Shenzhen 518108， Guangdong， China）

【Abstract】ObjectiveTo analyze the influencing factors of ventilation dysfunction in children with mycoplasma pneumonia. MethodsRetrospective analysis was carried out on the clinical data of 80 children with mycoplasma pneumonia treated in Shiyan People's Hospital of Bao'an District of Shenzhen from October 2018 to October 2020. All children underwent pulmonary function test. And then， children with ventilation dysfunction were included in occurrence group and children without ventilation dysfunction were included in non occurrence group. The clinical data of all children were counted to analyze the influencing factors of ventilation dysfunction in children with mycoplasma pneumonia. ResultsOf the 80 included children with mycoplasma pneumonia， 18 had ventilation dysfunction， with an incidence of 22.50%. After the preliminary comparison of general data of the two groups， the eligible variables were included in the study respectively. Logistic regression analysis showed that long fever time， overexpressions of C-reactive protein （CRP）， procalcitonin （PCT） and monocyte chemoattractant protein （MCP）-1 were the influencing factors of ventilation dysfunction in children with mycoplasma pneumonia （OR > 1， P < 0.05）. ConclusionThe risk of ventilation dysfunction in children with mycoplasma pneumonia is high. Long fever time， overexpressions of CRP， PCT and MCP-1 are the influencing factors of ventilation dysfunction in children with mycoplasma pneumonia.

【Key words】mycoplasma pneumonia; ventilation dysfunction; fever time; CRP; PCT; MCP-1

支原體肺炎（mycoplasma pneumonia，MP）不仅发病率高、进展快，且病情迁延可加重肺功能损伤，增加其他并发症发生风险，不利于患儿预后[1]。通气功能障碍是支原体肺炎并发症之一，不仅影响患儿肺功能发育，加重肺损伤程度，严重可危及患儿生命安全[2]。因此，积极预防通气功能障碍的发生十分重要。目前，有研究发现，病程、既往史等因素会加重肺炎患儿病情程度，进而加重肺损伤，可能会增加通气功能障碍风险[3]。……