张忠刚

【摘 要】目的：探究分析高原地区小儿慢性咳嗽治疗中应用孟鲁司特钠联合布地奈德治疗的有效性。方法：选取2020年7月至2021年7月我院收治的小儿慢性咳嗽患儿86例，采取数字1：1随机法分为对照组43例与试验组43例，给予对照组患儿布地奈德治疗，试验组在上述基础上联合孟鲁司特钠治疗，对比两组肺功能指标及治疗总有效率情况。结果：试验组患儿呼气峰流速（PEF）、用力肺活量（FVC）及用力呼气容积（FEV1）明显优于对照组，有统计学差异（P<0.05）；试验组与对照组治疗总有效率分别为95.35%、74.42%，试验组较对照组高，有统计学差异（P<0.05）。结论：高原地区小儿慢性咳嗽经孟鲁司特钠联合布地奈德治疗可提高患儿肺功能，疗效确切，安全性高，具有较高的临床推广及应用价值。

【关键词】慢性咳嗽；小儿；布地奈德；孟鲁司特钠

Analysis of the Effectiveness of Montelukast Sodium and Budesonide in the Treatment of Childrens Chronic Cough in High Altitude Area

Zhang Zhonggang

Emergency Department， Women and Childrens Hospital of Qinghai Province， Qinghai Xining 810007，China

【Abstract】Objective：To explore and analyze the effectiveness of montelukast sodium combined with budesonide in the treatment of chronic cough in children at high altitude.Methods： A total of 86 children with chronic cough treatedin our hospital from July 2020 to July 2021 were selected and randomly divided into the control group of 43 cases and thetest group of 43 cases by thenumber 1：1 random method， and the control group was given budesonidetreatment， the test group was givenmontelukast sodium treatment on the basis of the above， and the pulmonary function indexes and the total effective rate of treatment were compared between the two groups. Results： The peak expiratory flow rate （PEF）， forced vital capacity （FVC） and forced expiratory volume （FEV1） of the children in the test group were significantly better than those in the control group， with statistical differences（P<0.05）；The total effective rate ofthe test group and the control group were 95.35% and 74.42%respectively， the test group was higher than the control group， there was a statistical difference（P<0.05）.Conclusion：Montelukast sodium combined with budesonide treatment in children with chronic cough in plateau areas can improve the lung function of children， with definite curative effect， high safety， and high clinical promotion and application value.

【Key？Words】Chronic cough； Children； Budesonide； Montelukast sodium

臨床常见的呼吸系统疾病之一为慢性咳嗽，多发于儿童，临床以反复性咳嗽或持续性咳嗽为主要表现[1]。因疾病缺乏特异性症状，极易发展成慢性支气管炎，若不能准确诊断，给小儿学习及生活带来不良影响。临床治疗慢性咳嗽尚未有统一的治疗方案。因此，在治疗中应对炎症因子水平进行有效控制。本研究选取我院收治的86例小儿慢性咳嗽患儿，43例给予布地奈德治疗，另外43例在上述基础上联合孟鲁司特钠治疗，分析其治疗有效性，现具体报道如下。

1 资料与方法

1.1 临床资料

选取2020年7月至2021年7月我院收治的小儿慢性咳嗽患儿86例，采取数字1：1随机法分为对照组43例与试验组43例。对照组，男27例，女16例，年龄3岁～12岁，平均年龄（6.21±0.76）岁，病程2个月～4个月，平均病程（1.54±0.19）个月。试验组，男26例，女17例，年龄4岁～12岁，平均年龄（6.24±0.79）岁，病程2个月～4个月，平均病程（1.55±0.18）个月。纳入标准：满足慢性咳嗽相关诊断标准；临床资料完善；患者及其家属知晓且同意本次研究，经医院伦理委员会批准，签署知情同意书。……