刘东 李晓

摘  要：目的  探討布地奈德雾化联合沙丁胺醇治疗支气管哮喘的效果及其对患者白三烯（LTs），嗜酸性粒细胞（EOS）浓度及炎性因子水平的影响。方法  选择2018年9月～2021年5月山东省枣庄市肿瘤医院收治的90例支气管哮喘患者为研究对象，随机数表法分为对照组与研究组，各45例，对照组接受布地奈德雾化吸入治疗，研究组在对照组基础上加沙丁胺醇，对两组治疗效果、治疗前后肺功能及血气分析指标进行比较。结果  研究组治疗总有效率明显高于对照组（P<0.05）;两组治疗前的呼气流速峰值（PEFR）、用力肺活量（FVC）、第一秒用力呼气量（FEV1）无明显差异（P>0.05），研究组治疗后上述指标明显高于对照组（P<0.05）;两组治疗前的动脉氧分压（PaO2）、动脉二氧化碳分压（PaCO2）无明显差异（P>0.05），研究组治疗后上述指标明显低于对照组（P<0.05）;治疗后，研究组LTs、IL-17、EOS水平显著低于对照组（P<0.05）。结论  布地奈德雾化联合沙丁胺醇治疗支气管哮喘效果满意，可有效改善肺功能与血气分析指标，降低患者LTs，EOS浓度及炎性因子水平。

关键词：布地奈德雾化;沙丁胺醇;支气管哮喘;LTs;EOS;炎性因子

中图分类号：R56    文献标识码：A    文章编号：1009-8011（2021）-13-0008-04

The effect of budesonide nebulization combined with salbutamol in the treatment of bronchial asthma and its influence on the levels of LTS， EOS and inflammatory factors in patients

LIU Dong1  LI Xiao2

Abstract： Objective  To investigate the effect of budesonide nebulization combined with salbutamol in the treatment of bronchial asthma and its effect on the concentration of leukotrienes（LTs）， eosinophils（EOS） and the levels of inflammatory factors in patients. Methods  From September 2018 to May 2021， 90 patients with bronchial asthma admitted to Zaozhuang Tumor Hospital in Shandong Province were selected as the research objects. They were divided into control group and study group by random number table， with 45 cases in each group. The control group received budesine In German nebulization inhalation treatment， the study group added salbutamol on the basis of the control group， and compared the treatment effects， lung function and blood gas analysis indexes of the two groups before and after treatment. Results  The total effective rate of treatment in the study group was significantly higher than in the control group（P<0.05）; the peak expiratory flow rate（PEFR）， forced vital capacity（FVC）， and forced expiratory volume in the first second of the two groups before treatment（FEV1） there was no significant difference（P>0.05）. The above indicators in the study group after treatment were significantly higher than those in the control group（P<0.05）; the arterial partial pressure of oxygen（PaO2） and arterial carbon dioxide（PaCO2） before treatment in the two groups were not Significant difference（P>0.05）. After treatment， the above indicators in the study group were significantly lower than those in the control group（P<0.05）; after treatment， the levels of LTs， IL-17 and EOS in the study group were significantly lower than those in the control group（P<0.05）. Conclusion  The effect of budesonide nebulization combined with salbutamol in the treatment of bronchial asthma is satisfactory. It can effectively improve lung function and blood gas analysis indexes， and reduce the concentration of LTs， EOS and inflammatory factors in patients.

Keywords： budesonide atomization; salbutamol; bronchial asthma; LTs; EOS; inflammatory factors

支气管哮喘属于呼吸科常见疾病，主要表现为咳嗽、胸闷、气促、喘息等，具有反复发作的特点，若未及时对病情加以控制，不仅影响患者生活质量，严重者甚至因救治不及时危及生命[1]。沙丁胺醇属于β受体短效激动剂，布地奈德属于糖皮质激素，两者联合应用以雾化方式给药，具有起效快、操作方便、不良反应轻、连续性好等优势，是目前治疗支气管哮喘常用手法，可有效缓解症状，但是远期效果不佳[2]。基于此，为探寻支气管哮喘最佳治疗方案，本研究将布地奈德雾化联合沙丁胺醇治疗应用于支气管哮喘患者的临床治疗中，旨在对其疗效进行探讨，报道如下。

1  资料与方法

1.1  一般资料

选择2018年9月～2021年5月山东省枣庄市肿瘤医……