阿拉木斯

[关键词] 艾司西酞普兰;抑郁;酒精依赖;生活质量

[中图分类号] R749.41          [文献标识码] B          [文章编号] 1673-9701（2021）20-0101-03

Effect of escitalopram in treatment of alcohol dependence with depression and its effect on quality of life of patients

A Lamusi

Addiction Medicine Center，Inner Mongolia Mental Health Center， Huhehot    010010， China

[Abstract] Objective To explore and analyze the effect of escitalopram in treatment of alcohol dependence with depression and its effect on quality of life of patients. Methods Research subjects were selected from January 2019 to April 2020， and all the 72 patients with depression and alcohol dependence were admitted to our hospital for treatment. According to the random number table， 36 patients in the conventional group were treated with conventional alcohol detoxication therapy， and 36 patients in the study group were treated with escitalopram in addition to the conventional group. The changes of depression mood， sleep quality， alcohol dependence and social dysfunction， quality of life and the rates of adverse reactions were statistically analyzed between the routine group and the study group. Results After treatment， the HAMD score， PQI score， alcohol dependence score and social function deficit score in the study group were lower than those in the control group， and the GQOL-74 scores in mental health， material life， physical health and social function were higher than those in the control group， and the differences were statistically significant（P<0.05）. No significant difference was observed in the total rate of adverse reaction rate between the conventional group and the study group（P>0.05）. Conclusion Escitalopram can effectively relieve depression， improve sleep quality， reduce alcohol dependence， improve social function of patients， and effectively improve the quality of life of patients with high drug safety， which is worthy of promotion.

[Key words] Escitalopram; Depression; Alcohol dependence; Quality of life

酒精依賴的出现通常与患者长期饮酒有关，饮酒过量、持续饮酒时间过长会使得患者难以控制饮酒行为，无法对自身行为进行约束，并最终致使酒精依赖发生[1-2]。酒精依赖症状不仅会对患者生理功能产生负面影响，还会在患者心理层面构成情绪干扰，患者容易因此出现焦虑、烦躁情绪[3-4]。据相关研究统计结果数据显示，酒精依赖患者更容易出现精神障碍症状，其发生率为正常人群的2～4倍，其中同时伴发抑郁症状的酒精依赖患者群体的总占比大约为10%[5-6]。抑郁情绪的出现会导致酒精依赖患者睡眠质量降低，对患者的戒酒效果产生严重负面影响[7]。本研究旨在探讨分析艾司西酞普兰治疗伴抑郁酒精依赖的效果及对患者生活质量的影响，现报道如下。

1 资料与方法

1.1一般资料

选取2019年1月至2020年4月于我院就诊治疗的72例伴抑郁酒精依赖患者。纳入标准：患者病情符合伴抑郁酒精依赖诊断标准[8]。排除标准[9]：认知异常者、沟通困难者、对研究药物过敏者。采用随机数字表法分为两组，每组各36例。常规组患者采用常规酒精脱依赖治疗，研究组患者在常规组基础上应用艾司西酞普兰治疗。其中所有患者均为男性，常规组年龄25～53岁，平均（33.69±6.38）岁，饮酒时间6～18年，平均（10.47±3.14）年。研究组年龄26～54岁，平均（34.13±6.17）岁，饮酒时间6～18年，平均（10.56±3.22）年。两组患者临床资料比较，差异无统计学意义（P>0.05），具有可比性。该研究经医院医学伦理标准委员会批准，所有研究对象均知情且同意参与。