陆莉萍　　邵永良　　沈仲夏

[关键词] 重性抑郁症;低频振幅;静息态功能;磁共振成像

[中图分类号] R749.4          [文献标识码] B          [文章编号] 1673-9701（2021）19-0128-04

Observation on resting-state functional magnetic resonance imaging results of major depressive disorder based on the amplitude of low-frequency fluctuations

LU Liping   SHAO Yongliang   SHEN Zhongxia

Department of Radiology， Huzhou Third Municipal Hospital in Zhejiang Province， Huzhou   313000， China

[Abstract] Objective To explore the results of resting functional magnetic resonance imaging （fMRI） of major depressive disorder （MDD） based on the amplitude of low-frequency fluctuations （ALFF）. Methods A total of 35 patients with MDD who visited our psychological clinic from January 2017 to January 2019 were prospectively selected as the MDD group. 35 healthy volunteers who had physical examination in our hospital in the same period were selected as the control group. mALFF values （obtained by the M processing of ALFF value） of different brain regions in fMRI were compared between the two groups. Results mALFF values of right prefrontal cortex， right superior temporal gyrus， right inferior temporal gyrus， left insula， left medial frontal gyrus and left direct gyrus in MDD group were significantly higher than those in the control group， and the differences were statistically significant（P<0.05）. mALFF values of bilateral supplementary motor areas， right lingual gyrus， left anterior cuneiform lobe and left lingual gyrus in MDD group were significantly lower than those in the control group， and the differences were statistically significant（P<0.05）. Conclusion mALFF values of right prefrontal cortex， right superior temporal gyrus， right inferior temporal gyrus， left insular lobe， left medial frontal gyrus and left direct gyrus increase， while mALFF values of bilateral supplementary motor areas， bilateral lingual gyrus and left anterior cuneiform lobe decrease in MDD patients at rest， which may lead to the basis of MDD.

[Key words] Major depressive disorder; The amplitude of low-frequency fluctuations; Resting state functional; Magnetic resonance imaging

重性抑郁癥（Major depression disorder，MDD）临床患病率、复发率、自杀率等均较高，不仅会对患者身心健康造成严重损害，而且也给家庭、社会带来较重的经济负担[1]。因此，如何有效改善MDD患者的症状意义重大。目前，抑郁症的发病机制尚不清晰，明确致病因素仍存在争议。随着大脑影像学技术的发展，基于大脑影像学探索抑郁症可能发病机制，为MDD的有效治疗提供新的方法成为临床研究的重点。功能磁共振成像（Functional magnetic resonance imaging，fMRI）技术是一种非入侵的新兴神经影像学检查方法，可利用磁共振造影来显示大脑特定区域神经元活动引发的血液动力的改变[2]。因抑郁症表现为持续性症状，故静息态fMRI技术应用于抑郁症研究具有一定前景。近年来，已有报道[3-4]将低频振幅（Amplitude of low frequency fluctuation，ALFF）用于阿尔茨海默症、精神分裂症等功能性精神障碍进行探究，用于抑郁的也有一些报道，但相对较少，且纳入样本包括轻或中度抑郁症，而本研究仅纳入危害较大的重度抑郁症，通过观察其基于ALFF的静息态fMRI成像结果，分析MDD患者脑部自发性神经活动情况，以期为重性抑郁症的诊疗提供参考，现报道如下。