温胆汤合半夏白术天麻汤治疗高血压的疗效
2021-08-11邢勇胜杨曼
邢勇胜 杨曼



摘 要 目的:探讨温胆汤合半夏白术天麻汤对高血压的临床疗效。方法:选取146例高血压患者,随机分为对照组和观察组各73例。对照组采用西医常规治疗,观察组在对照组的基础上给予温胆汤合半夏白术天麻汤治疗,比较两组患者的疗效。结果:观察组总有效率高于对照组;治疗后观察组患者全血高切黏度、全血低切黏度、血浆黏度、TXA2、NPY和ET-1水平均低于对照组(P<0.05)。结论:温胆汤合半夏白术天麻汤可降低高血压患者的血压,改善血液流变学指标,减少缩血管物质的分泌。
关键词 高血压 温胆汤 半夏白术天麻汤 厄贝沙坦 血液流变学
中图分类号:R289.5; R544.1 文献标志码:A 文章编号:1006-1533(2021)13-0030-02
Effect of Wendan decoction and Banxia Baizhu Tianma decoction in the treatment of hypertension
XING Yongsheng, YANG Man
(Department of Rehabilitation Medicine, the Third Peoples Hospital of Henan Province, Zhengzhou 450000, China)
ABSTRACT Objective: To investigate the clinical effect of Wendan decoction and Banxia Baizhu Tianma decoction on hypertension. Methods: One hundred and forty-six patients with hypertension were randomly divided into a control group and an observation group with 73 cases each. The control group was conventionally treated with western medicine, and the observation group was treated with Wendan decoction and Banxia Baizhu Tianma decoction on the basis of the control group, and the efficacy was compared between the two groups. Results: The total effective rate was higher and the whole blood high and low shear viscosity, the plasma viscosity, the levels of TXA2, NPY and ET-1 were lower in the observation group than the control group after treatment (P<0.05). Conclusion: Wendan decoction combined with Banxia Baizhu Tianma decoction can reduce blood pressure and the secretion of vasoconstrictor substances and improve hemorheology indexes in patients with hypertension.
KEy WORDS hypertension; Wendan decoction; Banxia Baizhu Tianma decoction; irbesartan; hemorheology
近年來,受到不良生活习惯等因素影响,高血压在中国的发病率高达20%左右,且呈逐年上升的趋势[1]。但目前中国老年高血压患者的治疗率和控制率仅为32.2%和7.6%[2]。对于高血压的治疗,西药虽然在一定程度上可以控制患者的血压,但西药存在耐受性差、不良反应发生率高等缺点[3]。研究[4]表明,高血压患者由于血管壁压力高于正常值,刺激血栓素A2(thromboxane A2,TXA2)等缩血管物质的分泌,进而使血黏度增高,血压进一步升高,最终影响心脏功能。临床实践经验[5]表明,中医药在治疗高血压方面优势明显,可有效降低患者的血压,改善血液流变学指标,减轻高血压引起的器官损伤,提升心肾功能。
1 临床资料
1.1 一般资料
选取河南省直第三人民医院收治的146例高血压患者,随机分为对照组和观察组各73例。其中对照组男性41例,女性32例;年龄42~75岁,平均年龄(60.16±4.51)岁;病程1~7年,平均病程(3.01±1.02)年;高血压分级为Ⅰ级50例,Ⅱ级23例。观察组男性42例,女性31例;……
