曹媛　　闵钟云

[關键词] 血流动力学;突发性耳聋;巴曲酶;银杏达莫

[中图分类号] R764          [文献标识码] B          [文章编号] 1673-9701（2021）14-0080-04

Observation of the curative effect of Batroxobin combined with Yinxing Damo on sudden deafness

CAO Yuan1   MIN Zhongyun2

1.Department of Otorhinolaryngology， Dalian Municipal Women and Children′s Medical Center， Dalian   116033， China; 2.Department of Otorhinolaryngology， Ansteel Group General Hospital， Anshan   114001， China

[Abstract] Objective To study the value of Batroxobin combined with Yinxing Damo for sudden deafness. Methods A total of 76 patients with sudden deafness enrolled in our hospital from March 2018 to March 2020 were selected and divided into two groups according to the random double-blind method， with 38 cases in each group. The study group was given Batroxobin and Yinxing Damo， and the control group was given Batroxobin. The effective rate of patients after the medication was evaluated. The coagulation function indexes including PT （prothrombin time）， TT （blood enzyme time）， ATPP （activated partial prothrombin time）， PF （platelet factor）， FIB （fibrinogen）]， hemorheology indexes including HS （high shear viscosity）， PV （plasma viscosity）， LS （low shear viscosity）， MS （medium shear viscosity）， serum indexes including NO （nitric oxide）， ET （endothelin）， SVCAM-1 （vascular cell adhesion factor-1）， SOD （superoxide dismutase） of the two groups before and after medication were measured. The incidence of all patients′ adverse reactions （dizziness， nausea， vomiting， allergies， etc.） was observed. And the medication results of the two groups were compared. Results The effective rate of the study group was 92.11%， higher than that （71.05%） of the control group （P<0.05）. There was no difference in the incidence of adverse reactions between the two groups （P>0.05）. There was no difference in the coagulation function indexes between the two groups before treatment（P>0.05）. After treatment， PT， TT， and ATPP in the study group were higher than those in the control group， but PF and FIB were lower than those in the control group （P<0.05）. There was no difference in hemorheological indexes between the two groups before treatment（P>0.05）. After treatment， HS， PV， LS， and MS in the study group were lower than those in the control group（P<0.05）. There was no difference in serum indexes between the two groups before treatment （P>0.05）. After treatment， NO， ET， and sVCAM-1 in the study group were lower than those in the control group， but SOD was higher than the control group（P<0.05）. Conclusion Batroxobin combined with Yinxing Damo is more effective in sudden deafness， which can improve patients′ coagulation function， promote the recovery of hemorheology， prevent serious adverse reactions， and has high safety.

[Key words] Hemodynamics; Sudden deafness; Batroxobin; Yinxing Damo

突发性耳聋通常是指突然发生且原因不明的感音神经性听力损伤，其中相邻的两个频率听力降低超出20 dB HL，成为耳鼻喉科常见疾病。临床症状以耳鸣、眩晕、耳闷等为主，部分轻度患者可自行痊愈，但症状严重者可能需要给予有效治疗，否则随着疾病持续加重，其听力水平明显降低，甚至失去听力功能，给患者日常生活及工作带来严重后果[1-2]。研究指出[3]，疾病的发生机制可能与血液感染、病菌等因素存在一定关联，一旦自由基不断增多后，可牵连患者机体多个器官功能受损，但目前临床缺少针对性治疗方案，因此寻求科学合理的治疗方式成为关键[4]。临床以往多选择药物进行治疗，其中以巴曲酶较为多见，虽然能够改善患者的听觉能力，并减轻相应症状，但其单一用药的效果较为局限，无法快速稳定病情，从而导致预后较差[5]。随着医学技术的迅猛发展，临床认为在此基础上，增加银杏达莫的效果更好，可有效改善患者局部微循环，并促进耳缺血情况恢复，有效控制疾病，减低痛苦，为预后提供保障[6]。本文展开实验，现报道如下。

1 资料与方法

1.1 一般资料

选择我院2018年3月至2020年3月纳入的76例突发性耳聋患者，依据随机双盲法分成两组，每组各38例。研究组男21例，女17例，年龄23～68岁，平均（42.69±1.24）岁，病程10 h～30 d，平均（17.59±2.03）d，左耳25例，右耳13例;对照组男20例，女18例，年龄24～68岁，平均（42.23±1.17）岁，病程10 h～28 d，平均（17.11±2.25）d，左耳22例，右耳16例。两……