李晓燕

[摘要] 目的 針对卵巢肿瘤手术治疗患者术后采用还原型谷胱甘肽辅助治疗后的整体效果进行研究分析。 方法 2018年10月至2020年7月随机抽取我院收治的卵巢肿瘤手术治疗患者66例;给予统一编号后按照单双数分为实验组和常规组，每组各33例。分别在术后给予常规化学药物治疗和还原型谷胱甘肽辅助治疗，以对比两种治疗方案对患者机体T淋巴细胞亚群水平、抗氧化功能及炎症因子水平的改善情况。 结果 两组治疗前的相关指标比较，差异无统计学意义（P>0.05）;治疗后的实验组 T 淋巴细胞亚群水平、抗氧化功能指标及血清炎症因子水平改善情况均优于常规组，差异有统计学意义（P<0.05）。 结论 临床针对卵巢肿瘤手术治疗患者术后采用还原型谷胱甘肽辅助治疗后的整体效果显著，具有一定的临床推广和应用价值。

[关键词] 卵巢肿瘤;手术治疗;还原型谷胱甘肽;机体免疫功能;抗氧化功能;炎症因子水平;改善情况

[中图分类号] R737.3          [文献标识码] B          [文章编号] 1673-9701（2021）14-0070-03

Improvement of immune function of organism，antioxidant function and inflammatory factor level by applying reduced glutathione adjuvant after ovarian tumor surgery

LI Xiaoyan

Department of Obstetrics and Gynecology， Xiangyang Hospital of Traditional Chinese Medicine in Hubei Province， Xiangyang Institute of Traditional Chinese Medicine， Xiangyang   441000， China

[Abstract] Objective To research and analyze the overall efficacy of reduced glutathione adjuvant therapy for patients with ovarian tumor after surgery. Methods A total of 66 patients with ovarian tumor admitted to our hospital from October 2018 to July 2020 were randomly selected，and they were divided into the experimental group and the conventional group，with 33 cases in each group after being uniformly numbered according to singular and even numbers after surgery. The experimental group was treated with reduced glutathione adjuvant therapy，while the conventional group was treated with conventional chemotherapy. And the improvement of T lymphocyte subsets，antioxidant function and inflammatory factor level of patients by the two treatment schemes was investigated in a comparative way. Results Before treatment，there were no statistically significant differences in the related indexes between the conventional group and the experimental group（P>0.05）. After treatment，the improvement of T lymphocyte subsets，antioxidant function indexes and serum inflammatory factors in the experimental group were all superior to those in the conventional group，with statistically significant differences（P<0.05）. Conclusion In clinical practice，the overall efficacy of reduced glutathione adjuvant therapy for patients with ovarian tumor after surgery is remarkable，it has certain clinical promotion and application value.

[Key words] Ovarian tumor; Surgical treatment; Reduced glutathione; Immune function of organism; Antioxidant function; Inflammatory factor level; Improvement

据统计[1]，在我国卵巢肿瘤疾病中约20%均发生于月经来潮前的女孩，2/3来源于生殖细胞，且近年来该疾病的发病趋势逐渐向年轻化发展，对于患者的日常生活质量及身体健康均造成了一定的影响。临床通常给予卵巢肿瘤患者手术方式进行治疗，且术后实施一定的化疗方案进行辅助，以整体提高患者的临床治疗及预后效果[2]。但是，长期的药物化疗治疗会使患者的免疫功能受损，并导致其抗氧化功能下降，机体炎症因子出现不同程度释放，甚至还会给患者造成较差的预后效果[3];因此，本研究将随机抽取我院于2018年10月至2020年7月期间收治的卵巢肿瘤手术治疗患者66例，术后化疗中给予还原型谷胱甘肽药物进行辅助，并分析其对患者机体免疫功能、抗氧化功能及炎症因子水平的改善情况，现报道如下。