朱小丽　　胡金喜

[摘要] 目的 分析代謝综合征（MS）相关指标与结直肠癌患者行根治术术后预后的影响。 方法 选取2010年12月至2013年11月在本院行结直肠癌根治术治疗的患者234例，收集患者的临床信息及实验室检测指标，跟踪随访患者术后情况，用生存曲线分析糖尿病、脂代谢紊乱、高血压及肥胖对患者术后预后的影响。 结果 234例结肠癌患者中，MS患者占8.11%，糖尿病、脂代谢紊乱、高血压及肥胖患者分别占23.93%、26.06%、28.20%及15.38%。高血压患者发生术后并发症的比例显著高于非高血压患者，差异有统计学意义（P=0.013）。经年龄校准，肥胖是结直肠癌死亡的高风险因素[HR：1.11（1.01～1.22），P=0.041]。MS对结直肠癌患者术后总生存期（OS）并无明显影响（P=0.722）;高血压患者OS短于非高血压患者，差异有统计学意义（P<0.01）。 结论 高血压是结直肠癌根治术患者术后并发症发生及影响OS的不利因素，肥胖是结直肠癌死亡的高风险因素。

[关键词] 代谢综合征;结直肠癌;根治术;预后

[中图分类号] R735.3          [文献标识码] B          [文章编号] 1673-9701（2021）09-0134-05

The influence of metabolic syndrome related indicators on the prognosis of colorectal cancer patients undergoing radical resection

ZHU Xiaoli1   HU Jinxi2

1.Department of Clinical Laboratory， Taizhou Hospital of Zhejiang Province， Taizhou   317000， China; 2.Department of Tumor Surgery， Taizhou Hospital of Zhejiang Province， Taizhou   317000， China

[Abstract] Objective To analyze the influence of metabolic syndrome （MS） related indicators on the prognosis of patients with colorectal cancer after radical resection. Methods Clinical information and laboratory indexes of 234 patients undergoing radical resection of colorectal cancer in our Hospital from December 2010 to November 2013 were collected. The postoperative status of the patients was followed up. The survival curve was used to analyze the influence of diabetes， lipid metabolism disorder， hypertension and obesity on postoperative prognosis of the patients. Results Among the 234 colon cancer patients， 8.11% were MS patients， 23.93% were diabetes， 26.06% were lipid metabolism disorder， 28.20% were hypertension and 15.38% were obesity. The rate of postoperative complications in hypertensive patients was statistically significantly higher than that in non-hypertensive patients （P=0.013）. By age adjustment， obesity was a risk factor for colorectal cancer death （HR：1.11[1.01～1.22]， P=0.041）. MS had no significant effect on postoperative overall survival（OS） of colorectal cancer patients（P=0.722）， but the OS of hypertensive patients was shorter than that of non-hypertensive patients， and the difference was statistically significant（P<0.01）. Conclusion Hypertension is an adverse factor affecting postoperative complications and OS in patients undergoing radical resection for colorectal cancer， and obesity is a high risk factor for colorectal cancer death.

[Key words] Metabolic syndrome; Colorectal cancer; Radical resection; Prognosis

结直肠癌是全球最常见的癌症之一，在男性和女性中分别排在第3位和第2位，也是第4大癌症死亡原因[1]。流行病学调查分析结果显示，2018年我国男性结直肠癌患者占男性癌症患者的12.8%，女性结直肠癌患者占女性癌症患者的11.3%[2]，结直肠癌严重威胁人类健康。手术治疗是结直肠癌的主要治疗方法，术后5年生存率为50%[3]。代谢综合征（Metabolic syndrome，MS）是由糖尿病、高血压、肥胖及血脂代谢紊乱构成的一组综合性疾病，研究结果显示，MS在结直肠癌的发生中具有一定的促进作用[4]。本研究通过长期随访，分析MS相关因素对结肠癌预后的影响，现报道如下。

1资料与方法

1.1一般资料

选取2010年12月21日至2013年11月5日在浙江省台州医院行结直肠癌根治术治疗的患者234例。……