纪成波

[摘要] 目的 探討铝碳酸镁联合胃炎康胶囊治疗胆汁反流性胃炎的疗效。 方法 在我院2018年4月至2019年10月诊治的胆汁反流性胃炎患者中选出144例为对象，根据治疗方法分组：对照组患者应用铝碳酸镁治疗，观察组患者应用铝碳酸镁联合胃炎康胶囊治疗，对比两组患者的治疗总有效率、不良反应发生率以及血管活性肠肽水平（VIP）、IL-6水平、胃泌素水平、胃动素水平、胃酸分泌量、胆酸量。 结果 观察组患者治疗总有效率为97.22%，高于对照组的治疗总有效率（86.11%）（P<0.05）;观察组患者的不良反应发生率5.56%低于对照组的不良反应发生率（18.06%）（P<0.05）;观察组患者治疗后的VIP、IL-6以及胃泌素水平均低于对照组，且胃液中胆酸量和胃酸分泌量均低于对照组（P<0.01）;观察组胃动素水平高于对照组（P<0.01）。 结论 铝碳酸镁联合胃炎康胶囊在胆汁反流性胃炎患者中应用效果肯定，有助于改善胃肠激素水平，降低VIP、IL-6水平，减少胃内胆酸量和胃酸分泌，促进患者康复。

[关键词] 铝碳酸镁;胃炎康胶囊;胆汁反流性胃炎;胃肠激素;胃酸;胆酸

[中图分类号] R573.3          [文献标识码] B          [文章编号] 1673-9701（2021）09-0048-04

Observation on the effect of magnesium-aluminum carbonate combined with Weiyankang Capsule in the treatment of bile reflux gastritis

JI Chengbo

Department of Cardiology， Fengcheng Central Hospital in Liaoning Province， Fengcheng   118100， China

[Abstract] Objective To discuss and analyze the efficacy of magnesium-aluminum carbonate combined with Weiyankang Capsules in the treatment of bile reflux gastritis. Methods A total of 144 patients with bile reflux gastritis diagnosed and treated in our hospital from April 2018 to October 2019 were selected as subjects and grouped according to the treatment method. Patients in the control group were treated with magnesium-aluminum carbonate， and patients in the observation group were treated with magnesium-aluminum carbonate combined with Weiyankang Capsules. The total effective rate of the treatment， the incidence of adverse reactions， and the levels of vasoactive intestinal peptide（VIP）， IL-6， gastrin， and motilin， gastric acid secretion， the amount of bile acid between the two groups were compared. Results The total effective rate of treatment in the observation group was 97.22%， which was higher than the total effective rate of 86.11% in the control group（P<0.05）. The adverse reaction rate of the observation group was 5.56%， lower than that of the control group（18.06%）（P<0.05）. The VIP， IL-6， and gastrin levels of the observation group after treatment were lower than those of the control group， and the amount of bile acid and gastric acid secretion in the gastric juice were lower than those of the control group（P<0.01）. The motilin level of the observation group was higher than that of the control group（P<0.01）. Conclusion The magnesium-aluminum carbonate， combined with Weiyankang Capsules， positively affects patients with bile reflux gastritis. It helps to improve gastrointestinal hormone levels， reduce VIP and IL-6 levels， reduce the amount of bile acid and gastric acid secretion in the stomach， and promote patients′ recovery.

[Key words] Magnesium-aluminum carbonate; Weiyankang Capsule; Bile reflux gastritis; Gastrointestinal hormones; Gastric acid; Cholic acid

胆汁反流性胃炎（Bile reflux gastritis，BRG）是较为常见的一类胃炎，多数患者因消化道手术、幽门生理功能紊乱、胃肠结构异常等因素引起胆汁、胆酸、胰液等肠道内容物逆流到胃内，从而引起的胃黏膜慢性炎症性病变[1-2]。虽然该类胃炎的病情较轻微，但是若不能及时治疗，可能导致胃黏膜糜烂、胃溃疡，因此寻求积极有效的治疗方案具有重要临床意义[3-4]。目前该病尚无特效药物治疗，一般以抑酸剂、胃黏膜保护剂为主。铝碳酸镁是治疗胆汁反流性胃炎的常用药物，能有效增强胃肠动力，加速胃十二指肠运动，减少胃反流[5]。胃炎康胶囊具有疏肝和胃、缓急止痛之效[6]，本院将两药联合起来应用取得满意效果，现报道如下。

1 资料与方法

1.1 一般资料

选择我院2018年4月至2019年10月收治的胆汁反流性胃炎患者144例，纳入标准[7]：（1）符合胆汁反流性胃炎的诊断标准。……