陈鹏 马己才 陈俊斌

【摘要】 目的：探討血管内介入治疗急性脑梗死的临床效果及对患者VEGF、SOD、MDA水平的影响。方法：选取2017年1月-2019年12月本院收治的急性脑梗死患者180例。按治疗方法不同分为对照组和研究组，每组90例。对照组常规静脉溶栓治疗，研究组血管内介入治疗。比较两组治疗效果，比较两组治疗前后丙二醛（MDA）、超氧化物歧化酶（SOD）、血管内皮生长因子（VEGF）、神经生长因子（NGF）、脑钠肽（BNP）、神经元特异性烯醇化酶（NSE）水平及生活状况、神经功能评分。结果：研究组治疗总有效率高于对照组，差异有统计学意义（P<0.05）。治疗后，研究组MDA、SOD、VEGF水平均高于对照组，差异均有统计学意义（P<0.05）。治疗后，研究组生活状况、神经功能评分均优于对照组，差异均有统计学意义（P<0.05）。治疗后，研究组NGF高于对照组，BNP、NSE均低于对照组，差异均有统计学意义（P<0.05）。结论：急性脑梗死治疗中，血管内介入治疗效果肯定，值得推荐。

【关键词】 血管内介入 急性脑梗死 丙二醛 超氧化物歧化酶 血管内皮生长因子

Clinical Effect of Intravascular Interventional Therapy on Patients with Acute Cerebral Infarction and Its Influence on VEGF， SOD and MDA Levels/CHEN Peng， MA Jicai， CHEN Junbin. //Medical Innovation of China， 2021， 18（14）： -127

[Abstract] Objective： To investigate the clinical effect of intravascular intervention in the treatment of acute cerebral infarction and its influence on the levels of VEGF， SOD and MDA. Method： A total of 180 patients with acute cerebral infarction admitted to our hospital from January 2017 to December 2019 were selected. According to different treatment methods， they were divided into control group and research group， 90 cases in each group. The control group received routine intravenous thrombolysis， and the study group received intravascular intervention. The effects of treatment were compared between the two groups. The levels of malondialdehyde （MDA）， superoxide dismutase （SOD）， vascular endothelial growth factor （VEGF）， nerve growth factor （NGF）， brain natriuretic peptide （BNP）， neuron-specific enolase （NSE）， life status and neurological function scores were compared between the two groups before and after treatment. Result： The total effective rate of the study group was higher than that of the control group， the difference was statistically significant （P<0.05）. After treatment， MDA， SOD and VEGF levels in the study group were higher than those in the control group， the differences were statistically significant （P<0.05）. After treatment， the living status and neurological function scores of the study group were better than those of the control group， the differences were statistically significant （P<0.05）. After treatment， NGF in the study group was higher than that in the control group， BNP and NSE were lower than those in the control group， the differences were statistically significant （P<0.05）. Conclusion： In the treatment of acute cerebral infarction， intravascular interventional therapy is effective and worthy of recommendation.

[Key words] Intravascular intervention Acute cerebral infarction Malondialdehyde Superoxide dismutase Vascular endothelial growth factor

First-authors address： Yue Bei Peoples Hospital， Shaoguan 512000， China

doi：10.3969/j.issn.1674-4985.2021.14.030

急性脑梗死是临床神经内科常见脑血管疾病，在我国内外的发生率、致死率、致残率均较高，对人们的生命健康造成了严重的威胁[1]。急性脑梗死治疗关键为快速恢复闭塞血管血流，进而可以恢复脑组织血液，从而可以更好地减少脑神经功能损伤。缺血半暗带为临床进行溶栓治疗提供了依据[2]。使用常规药物治疗后患者的死亡率较高（90.0%），随着神经介入治疗技术的发展与进步，血管内溶栓治疗凭借着微创、可以更快地恢复患者脑组织血液流变学、血流动力学优势在临床上得到了广泛的使用，且效果较好[3]。但是以往临床研究多停留在表面，没有对作用机制等进行深入的分析，而本次研究对血管内介入治疗急性脑梗死的临床效果及对患者MDA、SOD、VEGF水平的影响进行了深入的分析，期望可以为临床治疗急性脑梗死患者提供依据。……