陈玉莲 喻群英

【摘要】 目的：探究与分析乙肝孕妇病毒载量对Th类细胞因子表达的影响。方法：选取本院2018年5月-2020年5月的100例乙肝孕妇为观察组，同时期的100例健康孕妇为对照组。比较两组妊娠早期及妊娠晚期的Th类细胞因子（IFN-γ、IL-10、IL-17及IL-23），比较观察组中不同病毒载量孕妇的上述指标检测结果，同时采用Spearman秩相关分析上述Th类细胞因子与乙肝孕妇病毒载量的关系。结果：观察组妊娠早期及妊娠晚期的Th类细胞因子均显著高于对照组，差异均有统计学意义（P<0.05）。观察组中不同病毒载量者妊娠早期及妊娠晚期的Th类细胞因子表达比较，差异均有统计学意义（P<0.05）。观察组中病毒载量较高孕妇的妊娠早期及妊娠晚期的Th类细胞因子均显著高于病毒载量较低孕妇，差异均有统计学意义（P<0.05）。Spearman秩相關分析显示，妊娠早期及妊娠晚期的Th类细胞因子与乙肝孕妇病毒载量均呈正相关（P<0.05）。结论：乙肝孕妇病毒载量对Th类细胞因子表达的影响较大，应注意对乙肝孕妇上述方面的监测与调控。

【关键词】 乙肝 孕妇 病毒载量 Th类细胞因子

Study on Influence of Viral Loads for Th Cytokines Expression of Pregnant Women with Hepatitis B/CHEN Yulian， YU Qunying. //Medical Innovation of China， 2021， 18（12）： -166

[Abstract] Objective： To explore and analyze the influence of viral loads on the expression of Th cytokines in pregnant women with hepatitis B. Method： A total of 100 pregnant women with hepatitis B in our hospital from May 2018 to May 2020 were selected as the observation group， and 100 healthy pregnant women in the same period were selected as the control group. The levels of Th cytokines （IFN-γ， IL-10， IL-17 and IL-23） in early pregnancy and late pregnancy were compared between two groups， and the above indexes of pregnant women with different viral loads in the observation group were compared. Meanwhile， Spearman rank correlation was used to analyze the relationship between Th cytokines and viral loads in pregnant women with hepatitis B. Result： The levels of Th cytokines in early and late pregnancy of the observation group were significantly higher than those in the control group， the differences were statistically significant （P<0.05）. The expression of Th cytokines in patients with different viral loads in early pregnancy and late pregnancy were compared in the observation group， the differences were statistically significant （P<0.05）. In the observation group， Th cytokines in early and late pregnancy of pregnant women with high viral load were significantly higher than those with low viral loads， the differences were statistically significant （P<0.05）. Spearman rank correlation analysis showed that Th cytokines in early and late pregnancy were positively correlated with HBV loads （P<0.05）. Conclusion： The viral loads of pregnant women with hepatitis B has a great influence on the expression of Th cytokines. We should pay attention to the monitoring and regulation of the above aspects of pregnant women with hepatitis B.

[Key words] Hepatitis B Pregnant women Viral loads Th cytokines

First-authors address： Xinzhou Maternal and Child Health Hospital， Wuhan 431400， China

doi：10.3969/j.issn.1674-4985.2021.12.039

乙肝在我国具有极高的发病率，而其涉及年龄段较广，在育龄妇女中的感染率也不低，因此与乙肝孕妇相关的各方面研究多见，加之母婴传播是本病的一类常见传染方式，其临床受重视程度进一步提升[1-2]。而乙肝感染所致机体免疫变化作为临床重点评估方面，其在乙肝孕妇中的变化研究可见，但是细致程度方面有所不足，Th类细胞因子作为免疫方面的重要组成部分[3-5]，其与乙肝孕妇病毒载量的关系研究仍有所不足。因此，本研究就乙肝孕妇病毒载量对Th类细胞因子表达的影响进行探究，现报道如下。

1 资料与方法

1.1 一般资料 选取本院2018年5月-2020年5月的100例乙肝孕妇为观察组，同时期的100例健康孕妇为对照组。纳入标准：20岁及以上;于本院进行规律产检的孕妇;单胎;观察组为乙肝孕妇，对照组为健康孕妇。排除标准：合并妊娠期疾病;合并高血压、糖尿病等慢性疾病;合并创伤;合并其他感染;认知障碍及精神病史;近期进行抗感染等治疗。……