苏耀荣 李超 何东添

【摘要】 目的：探究結直肠癌患者术后感染与蛋白代谢的关系。方法：选取2018年10月-2020年9月本院收治的40例结直肠癌术后感染患者为观察组，同时期的40例术后未发生感染患者为对照组。检测与比较两组术前及术后1、2 d蛋白代谢指标（血清TP、ALB及PA），比较观察组中不同感染情况（切口感染、盆腔感染及其他感染）患者的检测指标，采用Spearman相关性分析，术前及术后1、2 d蛋白代谢指标与结直肠癌患者术后感染的关系。结果：观察组术前及术后1、2 d蛋白代谢指标均显著低于对照组，差异均有统计学意义（P<0.05）。观察组中不同感染情况患者的检测指标比较，差异均无统计学意义（P>0.05）。Spearman相关性分析，术前及术后1、2 d蛋白代谢指标与结直肠癌患者术后感染均有密切关系（P<0.05）。结论：结直肠癌患者术后感染与蛋白代谢有密切的关系，应重视对结直肠癌患者围术期蛋白代谢的监测与干预。

【关键词】 结直肠癌 术后感染 蛋白代谢

Investigation on Relationship between Postoperative Infection and Protein Metabolism of Patients with Colorectal Cancer/SU Yaorong， LI Chao， HE Dongtian. //Medical Innovation of China， 2021， 18（12）： -122

[Abstract] Objective： To investigate the relationship between postoperative infection and protein metabolism of patients with colorectal cancer. Method： A total of 40 patients with postoperative infection of colorectal cancer from October 2018 to September 2020 were chosen as the observation group， 40 patients without postoperative infection at the same time were chosen as the control group. Then the protein metabolism indexes （serum TP， ALB and PA） of two groups before operation and 1 and 2 d after operation were detected and compared， then the detection indexes of the observation group with different infection situation （incision infection， pelvic infection and other infections） were compared， then the relationship between the protein metabolism indexes before operation and 1 and 2 d after operation and postoperative infection of patients with colorectal cancer were analyzed with Spearman correlation analysis. Result： The protein metabolism indexes of the observation group before operation and 1 and 2 d after operation were significantly lower than those of the control group， there were statistically significant differences （P<0.05）. The detection indexes of the observation group with different infection situation were compared， there were no statistically significant differences （P<0.05）. Spearman correlation analysis showed the protein metabolism indexes before operation and 1 and 2 d after operation were close with postoperative infection of patients with colorectal cancer （P<0.05）. Conclusion： The postoperative infection has close relationship to the protein metabolism of patients with colorectal cancer， and the protein metabolism of patients with colorectal cancer during the perioperative period should be paid to more monitoring and intervention.

[Key words] Colorectal cancer Postoperative infection Protein metabolism

First-authors address： Jiangmen Central Hospital， Jiangmen 529030， China

doi：10.3969/j.issn.1674-4985.2021.12.028

结直肠癌在临床多见，而手术作为本病的有效治疗方式，围术期的研究方面较多。术后感染作为常见术后并发症，其对患者的手术效果及预后均有较大的影响，因此是围术期的重点防控方面之一[1-2]。临床中与结直肠癌术后感染相关的研究中，与感染发生相关的研究虽可见，但是多集中于术后感染危险因素方面，与感染发生发展过程中的机体指标的变化研究极为不足。蛋白代谢作为与机体状态密切相关的方面，其与本类患者术后感染的关系仍有待深入探究[3-4]。因此，本研究就结直肠癌患者术后感染与蛋白代谢的关系进行探究，以为结直肠癌手术患者术后感染防控措施的制定提供参考依据，现报道如下。

1 资料与方法

1.1 一般资料 选取2018年10月-2020年9月本院收治的40例结直肠癌术后感染患者为观察组，同时期的40例结直肠癌术后未发生感染患者为对照组。……