邓刃锋 冯运红 金守梅

【摘要】 目的：觀察与研究左旋多巴在儿童弱视中的疗效及对视觉眼电图指标的影响。方法：选取2018年1月-2020年1月本院收治的108例弱视儿童为研究对象，将其随机分为常规治疗组（对照组）和常规治疗加左旋多巴组（观察组），每组各54例。比较两组治疗后不同时间的临床总有效率、治疗前及治疗后不同时间P-VEP及P-EGR相关指标、不良反应发生率。结果：观察组治疗3、6个月后临床总有效率均显著高于对照组，差异均有统计学意义（P<0.05）。两组治疗前P-VEP和P-EGR相关指标比较，差异均无统计学意义（P>0.05）;两组治疗3、6个月后P-VEP和P-EGR相关指标均持续改善，且观察组P-VEP和P-EGR潜时均显著低于对照组，P-VEP和P-EGR幅值均显著高于对照组，差异均有统计学意义（P<0.05）。两组不良反应发生率比较，差异均无统计学意义（P>0.05）。结论：左旋多巴在儿童弱视中的疗效较好，且对视觉眼电图指标的影响更为积极，因此在儿童弱视中的应用价值相对更高。

【关键词】 左旋多巴 儿童弱视 视觉眼电图指标

Observation on Effect of Levodopa in Children with Amblyopia and Influence for Visual Electrooculogram Indexes/DENG Renfeng， FENG Yunhong， JIN Shoumei. //Medical Innovation of China， 2021， 18（12）： 0-076

[Abstract] Objective： To observe and study the effect of Levodopa in the children with amblyopia and influence for visual electrooculogram indexes. Method： A total of 108 children with amblyopia from January 2018 to January 2020 were chosen as the research objects，and they were randomly divided into routine treatment group （the control group） and routine treatment and levodopa group （the observation group）， 54 cases in each group. The total effective rates at different time after treatment， P-VEP and P-EGR related indexes before treatment and at different time after treatment， adverse reactions rates of two groups were compared. Result： The total effective rates of the observation group at 3 and 6 months after treatment were significantly higher than those of the control group， there were statistically significant differences （P<0.05）. The P-VEP and P-EGR related indexes of two groups before treatment were compared， there were no statistically significant differences （P>0.05）; the P-VEP and P-EGR related indexes of two groups at 3 and 6 months after treatment were all continuously improved， and the P-VEP and P-EGR latent time of the observation group at 3 and 6 months after treatment were significantly lower than those of the control group， the P-VEP and P-EGR amplitude were significantly higher than those of the control group， there were statistically significant differences （P<0.05）. The adverse reactions rates of two groups were compared， there were no statistically significant differences （P>0.05）. Conclusion： The effect of Levodopa in the children with amblyopia is better， and its influence for visual electrooculogram indexes are more active， so the application value of Levodopa in the children with amblyopia is relatively higher.

[Key words] Levodopa Children with amblyopia Visual electrooculogram indexes

First-authors address： Longgang District Otorhinolaryngology Hospital of Shenzhen City， Shenzhen 518116， China

doi：10.3969/j.issn.1674-4985.2021.12.017

儿童弱视是眼科常见的儿童眼病，其可由多种原因导致，患儿的视觉功能减退，对其生活及学习等造成较大不良影响，因此是亟待改善与治疗干预的方面[1-2]。临床中与儿童弱视相关的研究显示，本类患儿的视觉眼电图指标中较多相对较差，因此也是临床疗效评估中的重要参考方面。左旋多巴是近年来在弱视中应用率持续升高的一类药物[3-5]，但是其细致的效果研究仍有所不足。因此，本研究就左旋多巴在儿童弱视中的疗效及对视觉眼电图指标的影响进行探究，现报道如下。

1 资料与方法

1.1 一般资料 选取2018年1月-2020年1月本院收治的108例弱视儿童为研究对象。……