赖坚

【摘要】 目的：探讨雌激素替代疗法结合滋肾疏肝方对围绝经期综合征患者的临床疗效。方法：选取2018年1月-2019年1月来本院接受治疗的80例围绝经期综合征的患者，随机分为两组，每组40例。对照组采用常规西药治疗，研究组则采用西药与滋肾疏肝方相结合的方法。比较两组治疗前后卵巢功能、Kupperman评分、血脂水平以及治疗后的临床效果。结果：治疗后，研究组FSH及Kupperman评分均低于对照组（P<0.05）;研究组临床治疗总有效率高于对照组（P<0.05）;研究组总胆固醇、甘油三酯及LDL-C均低于对照组（P<0.05），HDL-C高于对照组（P<0.05）。结论：对围绝经期综合征患者采用雌激素替代疗法结合滋肾疏肝方治疗，有助于改善其卵巢功能、临床症状与血脂水平，临床治疗效果好，值得推广与应用。

【关键词】 围绝经期综合征 雌激素替代疗法 滋肾疏肝方

Analysis of Clinical Efficacy of Estrogen Replacement Therapy Combined with Zishen Shugan Decoction on Patients with Perimenopausal Syndrome/LAI Jian. //Medical Innovation of China， 2021， 18（12）： 0-068

[Abstract] Objective： To explore the clinical effect of estrogen replacement therapy combined with Zishen Shugan Decoction on patients with perimenopausal syndrome. Method： A total of 80 patients with perimenopausal syndrome who came to our hospital for treatment from January 2018 to January 2019 were randomly divided in two groups， 40 patients in each group. The control group was treated with conventional western medicine， and the study group was treated with a combination of western medicine and Zishen Shugan Decoction. The ovarian function， Kupperman scores and blood lipid levels of two groups before and after treatment were compared， the clinical effect of two groups after treatment were compared . Result： After treatment， the FSH and Kupperman scores of the study group were lower than those of the control group （P<0.05）. The total effective rate of clinical treatment in the study group was higher than that of the control group （P<0.05）. The total cholesterol， triglyceride and LDL-C indexes of the study group were lower than those of the control group （P<0.05）， the HDL-C of the study group was higher than that of the control group （P<0.05）. Conclusion： Treatment of perimenopausal syndrome patients with estrogen replacement therapy combined with Zishen Shugan Decoction can help improve their ovarian function， clinical symptoms and blood lipid levels， and has a good clinical treatment effect， which is worthy of promotion and application.

[Key words] Perimenopausal syndrome Estrogen replacement therapy Zishen Shugan Decoction

First-authors address： Luoding City Maternal and Child Health Hospital， Luoding 527200， China

doi：10.3969/j.issn.1674-4985.2021.12.015

圍绝经期综合征又被称为更年期综合征，主要是指女性在绝经前后由于性激素波动或者降低而出现的自主神经功能紊乱，并伴有神经心理症状的疾病类型[1]。围绝经期主要包含绝经前期、绝经期以及绝经后期三个阶段。围绝经期综合征属于一种较为常见的妇科疾病，在女性围绝经期以及绝经后期因激素水平的改变，出现失眠、潮热以及多汗等临床症状[2]。该疾病涉及领域较为广泛，且极易复发，从而增加了治愈难度，严重影响女性的身体健康及生活质量水平[3]。目前，雌激素替代疗法由于服用方法简便、见效快等特点在临床中得到广泛应用，但随着药物服用时间延长，极易出现多种不良反应，对治疗效果的提升产生严重影响[4]。随着对中医研究的深入，采用中西医结合治疗的方案得到临床工作者的青睐。本研究通过对围绝经期综合征患者采用西药与滋肾疏肝方联合治疗，进而探讨其疗效。现报道如下。……