傅荣华 袁华 邹筠 金平亮 黄梦宇 程俊

【摘要】 目的：探讨聚桂醇联合博来霉素、地塞米松局部注射对颌面部血管瘤患儿免疫功能的影响。方法：选取2018年1月-2019年12月本院收治的84例颌面部血管瘤患儿为研究对象，按随机数字表法将其分为试验组和对照组，各42例。对照组行地塞米松和博来霉素治疗，试验组在对照组基础上行聚桂醇治疗。比较两组临床疗效、免疫功能及不良反应发生情况。结果：试验组治疗总有效率较对照组高，差异有统计学意义（P<0.05）。治疗后，试验组IgA、IgM、IgG水平均高于对照组，差异均有统计学意义（P<0.05）。试验组不良反应发生率为4.76%，低于对照组的19.05%，差异有统计学意义（P<0.05）。结论：颌面部血管瘤患儿行聚桂醇联合博来霉素、地塞米松局部注射安全性较高，能有效改善患儿病情，提高免疫功能，利于患儿早日康复。

【关键词】 颌面部血管瘤 聚桂醇 博来霉素 免疫功能

Effect of Local Injection of Lauromacrogol Combined with Bleomycin， Dexamethasone on Immune Function in Children with Maxillofacial Hemangioma/FU Ronghua， YUAN Hua， ZOU Yun， JIN Pingliang， HUANG Mengyu， CHENG Jun. //Medical Innovation of China， 2021， 18（10）： -149

[Abstract] Objective： To investigate the effect of local injection of Lauromacrogol combined with Bleomycin， Dexamethasone on immune function in children with maxillofacial hemangioma. Method： A total of 84 children with maxillofacial hemangioma treated in our hospital from January 2018 to December 2019 were selected as the research subjects， they were divided into experimental group and control group according to random number table method， 42 cases in each group. The control group was treated with Dexamethasone and Bleomycin， on this basis， the experimental group was treated with Lauromacrogol. The clinical efficacy， immune function and adverse reactions of the two groups were compared. Result： The total effective rate of experimental group was higher than that of control group， the difference was statistically significant （P<0.05）. After treatment， the levels of IgA， IgM and IgG in experimental group were higher than those in control group， the differences were statistical significance （P<0.05）. The incidence of adverse reactions in experimental group was 4.76%， which was lower than 19.05% in control group， the difference was statistically significant （P<0.05）. Conclusion： The local injection of Lauromacrogol combined with Bleomycin， Dexamethasone in children with maxillofacial hemangioma is safer， which can effectively improve the childrens condition， improve immune function， facilitate the childrens early recovery.

[Key words] Maxillofacial hemangioma Lauromacrogol Bleomycin Immune function

First-authors address： Jiangxi Provincial Childrens Hospital， Nanchang 330006， China

doi：10.3969/j.issn.1674-4985.2021.10.035

頜面部血管瘤是小儿常见的皮肤与软组织良性肿瘤，约占血管瘤的60%，具有病程进展快等特点，可破坏性影响患儿容貌与心理，甚至造成面部畸形，需尽早治疗[1-2]。博来霉素是治疗颌面部血管瘤常用的碱性糖肽类抗癌抗菌药物，可拮抗胸腺嘧啶核苷渗入DNA，结合DNA破坏其分解，或经抑制血管内皮细胞DNA合成，拮抗血管内皮细胞增生，对血窦内皮细胞形成破坏，促进肿瘤细胞坏死，造成血管瘤消退[3-5]。聚桂醇是一种具有局麻作用的硬化制剂，注射至静脉血管后能破坏血管内膜，促使血管与周围组织形成无菌性炎症，促进肉芽组织形成，最后形成纤维条索，阻碍血管内血流通过，发挥封闭血管管腔作用，逐渐应用于颌面部血管瘤治疗。本研究分析聚桂醇联合博来霉素、地塞米松局部注射对颌面部血管瘤患儿免疫功能的影响，旨在为临床治疗颌面部血管瘤提供参考，现报道如下。……