其其格

【摘要】 目的：探討纳洛酮联合注射用谷胱甘肽对急性重度酒精中毒患者的临床疗效及血清炎性因子水平的影响。方法：选取2018年5月-2020年7月本院收治的96例急性重度酒精中毒患者，按照随机数字表法将其分为对照组和研究组，各48例。对照组应用注射谷胱甘肽治疗，研究组在对照组基础上应用纳洛酮治疗。比较两组治疗60、120、180 min疗效、肢体运动与神志恢复正常时间、血清炎性因子水平、血清神经递质指标。结果：治疗60、120、180 min，研究组总有效率均高于对照组，差异均有统计学意义（P<0.05）。研究组肢体运动与神志恢复正常时间均短于对照组，差异均有统计学意义（P<0.05）。治疗后，研究组血清IL-8、TNF-α与水平均低于对照组，差异均有统计学意义（P<0.05）。治疗后12、24 h，研究组NO、AVP、β-EP均低于对照组，差异均有统计学意义（P<0.05）。结论：对急性重度酒精中毒患者治疗过程中，纳洛酮联合注射用谷胱甘肽的治疗效果理想，有效提高临床疗效，改善血清炎性因子的水平，临床上应进一步推广应用。

【关键词】 纳洛酮 注射用谷胱甘肽 急性重度酒精中毒 血清炎性因子

[Abstract] Objective： To investigate the clinical effect of Naloxone combined with Glutathione for Injection  for patients with acute severe alcoholism and its influence on serum inflammatory factors. Method： A total of 96 patients with acute severe alcoholism admitted to our hospital from May 2018 to July 2020 were selected， according to the random number table method they were divided into control group and study group， 48 cases in each group. The control group was treated with Glutathione for Injection， the study group was treated with Naloxone on the basis of the control group. The therapeutic effects of 60， 120， 180 min， recovery time of limb movement and consciousness， serum inflammatory factor levels and serum neurotransmitters were compared between two groups. Result： After 60， 120 and 180 min of treatment， the total effective rate of the study group were higher than those of the control group， the differences were statistically significant （P<0.05）. The recovery time of limb movement and consciousness in the study group were shorter than those in the control group， the differences were statistically significant （P<0.05）. After treatment， the serum levels of IL-8 and TNF-α in the study group were lower than those in the control group， the differences were statistically significant （P<0.05）. At 12 and 24 h after treatment， NO， AVP and β-EP in the study group were all lower than those in the control group， the differences were statistically significant （P<0.05）. Conclusion： In the treatment of patients with acute severe alcoholism， Naloxone combined with Glutathione for Injection has an ideal therapeutic effect， which can effectively improve the clinical efficacy and improve the level of serum inflammatory factors， which should be further promoted and applied in clinical practice.

[Key words] Naloxone Glutathione for Injection Acute severe alcoholism Serum inflammatory factor

First-authors address： Chifeng City Hospital， Chifeng 024000， China

doi：10.3969/j.issn.1674-4985.2021.03.017

在急诊科中急性重症酒精中毒属于急危重症，这是因为消化道的呕吐物和分泌物误吸，促使肺部发生感染，较多的酒精会破坏胃黏膜，进而导致消化性溃疡出血、胃部炎症，呕吐物还会导致气道被堵塞从而发生窒息，如果呼吸中枢被抑制可能会导致患者呼吸衰竭等[1]。较多的老年患者因为患有慢性疾病，一旦发生急性重度酒精中毒，会促使生命、健康均受到威胁[2]。在急救过程中，对急性重症酒精中毒患者实施针对性的治疗方法可以减少死亡、并发症事件发生，更好地维护健康[3]。本次研究选取2018年5月-2020年7月收治的急性重度酒精中毒患者96例，应用纳洛酮联合注射用谷胱甘肽治疗，疗效较为明显，现报道如下。

1 资料与方法

1.1 一般资料 选取2018年5月-2020年7月本院收治的96例急性重度酒精中毒患者。（1）诊断标准：符合《内科学》中对于急性乙醇中毒的诊断标准。……