谢芸 陈维平

【摘要】 目的：探究Hp促发自身免疫介导高血压患者血管壁炎症反应的作用。方法：选取2019年11月-2020年3月本院收治的100例原发性高血压伴Hp感染患者为观察组，同时期的100例仅原发性高血压患者为对照组。比较两组血清HSP-65、炎性反应指标（hs-CRP、IL-6、IL-8及TNF-α）和氧化应激反应指标（FFA、MDA及SOD），并比较观察组中不同CagA结果者的上述检测水平，并采用Spearman相关性分析血清HSP-65与血清炎性反应指标、氧化应激反应指标的关系。结果：观察组血清SOD显著低于对照组，血清HSP-65、FFA和MDA均显著高于对照组，差异均有统计学意义（P<0.05）。观察组中不同CagA检测结果者的血清HSP-65、炎性反应指标和氧化应激反应指标比较，差异均有统计学意义（P<0.05）。Spearman相关性分析显示，血清HSP-65与血清炎性反应指标、FFA及MDA均呈正相关，与SOD呈负相关（P<0.05）。结论：Hp可促发自身免疫介导高血压患者的血管壁炎症反应，应重视对Hp感染的防控与干预。

【关键词】 Hp 自身免疫 高血压 血管壁炎症反应

[Abstract] Objective： To investigate the role of Hp in promoting the inflammatory reaction of vascular wall mediated by autoimmunity in patients with hypertension. Method： A total of 100 patients with essential hypertension and Hp infection admitted to our hospital from November 2019 to March 2020 were selected as the observation group， and 100 patients with essential hypertension only during the same period were selected as the control group. Serum HSP-65， inflammatory response indicators （hs-CRP， IL-6， IL-8 and TNF-α） and oxidative stress indicators （FFA， MDA and SOD） were compared between two groups， and the above detection levels of different CagA results in the observation group were compared. Spearman correlation was used to analyze the relationship between serum HSP-65 and serum inflammatory response indicators， oxidative stress response indicators. Result： The serum SOD of the observation group was significantly lower than that of the control group， and the serum HSP-65， FFA and MDA were significantly higher than those of the control group， with statistically significant differences （P<0.05）. In the observation group， serum HSP-65， inflammatory response index and oxidative stress response index of different CagA test results were compared， the differences were statistically significant （P<0.05）. Spearman correlation analysis showed that serum HSP-65 was positively correlated with serum inflammatory response indicators， FFA and MDA， but negatively correlated with SOD （P<0.05）. Conclusion： Hp can promote autoimmune mediated vascular wall inflammation in patients with hypertension， so the Hp infection should be paid to prevention， control and intervention.

[Key words] Hp Autoimmunity Hypertension Inflammatory reaction of vascular wall

First-authors address： Xiangqiao District Peoples Hospital， Chaozhou 521000， China

doi：10.3969/j.issn.1674-4985.2021.03.016

高血壓的临床危害显著，而本病对心脑肾等靶器官的损害是临床的重点研究方面。有研究显示，血管壁炎症反应在本病患者中表现突出，本方面的研究也日益受到重视[1]。近年来关于高血压发生发展的研究增多，涉及面扩宽，而Hp感染与高血压的关系研究虽可见[2]，其对于高血压发生的影响作用仍极为欠缺。因此，本研究就Hp促发自身免疫介导高血压患者血管壁炎症反应的作用进行探究，以了解Hp感染在高血压患者中的影响机制，现报道如下。

1 资料与方法

1.1 一般资料 选取2019年11月-2020年3月本院收治的100例原发性高血压伴Hp感染患者为观察组，同时期的100例仅原发性高血压患者为对照组。（1）纳入标准：满足《中国高血压防治指南（2010年修订版）》中关于原发性高血压的诊断标准;年龄>20岁。（2）排除标准：急性冠脉综合征或糖尿病，或自身免疫疾病;恶性肿瘤;严重心、肺、肝、肾等脏器功能性不全;消化性溃疡、消化道出血等疾病;入组前1个月内有感染性疾病或慢性炎症疾病。患……