恒欣

【摘要】 目的：探讨肺力咳合剂联合喜炎平治疗急性支气管炎的临床效果。方法：回顾性选取2018年

11月-2019年10月于本院就诊的急性支气管炎患者174例作为研究对象，根据治疗方法将其分为试验组（n=89）和对照组（n=85），试验组患者给予肺力咳合剂联合喜炎平治疗，对照组患者单纯给予喜炎平治疗。分析两组血气指标、血清学变化，观察临床症状恢复时间。结果：治疗后，试验组IL-4、IL-8及PaCO2水平均低于对照组，IFN-γ水平，PaO2和SaO2水平均高于对照组，差异均有统计学意义（P<0.05）。治疗后，两组cTnI、hs-CRP、PCT水平均低于治疗前，且试验组均低于对照组，差异均有统计学意义（P<0.05）。试验组住院、止咳、胸片吸收、啰音消失及白细胞恢复正常时间均短于对照组，差异均有统计学意义（P<0.05）。试验组总有效率高于对照组，差异有统计学意义（P<0.05）。结论：在急性支气管炎的治疗中，肺力咳合剂与喜炎平的联合治疗方案对患者临床症状改善程度较快，缩短患者治疗时间，用药安全性高。

【關键词】 肺力咳合剂 喜炎平 急性支气管炎

Clinical  Study of Feilike Mixture Combined with Xiyanping in the Treatment of Acute Bronchitis/HENG Xin. //Medical Innovation of China， 2021， 18（01）： 0-049

[Abstract] Objective： To explore clinical study of Feilike Mixture combined with Xiyanping in the treatment of acute bronchitis. Method： A total of 174 patients with acute bronchitis admitted to our hospital from November 2018 to October 2019 were retrospectively studied， they were divided into the experimental group （n=89） and the control group （n=85） according to treatment methods. The experimental group was treated with Feilike Mixture combined with Xiyanping， while the control group was treated with Xiyanping alone. The changes of blood gas index and serology in the two groups were compared， the recovery time of clinical symptoms was observed. Result： After treatment， the levels of IL-4， IL-8 and PaCO2 in the experimental group were lower than those in the control group， the levels of IFN-γ， PaO2 and SaO2 in the experimental group were higher than those in the control group， with statistically significant differences （P<0.05）. After treatment， the levels of cTnI， hs-CRP and PCT in both groups were lower than those before treatment， the experimental group were lower than those in the control group， with statistically significant differences （P<0.05）. Hospitalization， cough relief， chest radiograph absorption， rhonchus disappearance and leukocyte recovery time in the experimental group were shorter than those in the control group， the differences were statistically significant （P<0.05）. The total effective rate of the experimental group was higher than the control group， the difference was statistically significant （P<0.05）. Conclusion： In the treatment of acute bronchitis， the combined treatment of Feilike Mixture and Xiyanping improved the clinical symptoms of patients faster， shortened the treatment time of patients， had high drug safety.

[Key words] Feilike Mixture Xiyanping Acute bronchitis

First-authors address： The PLA Air Force Hospital of the Northern War Zone， Shenyang 110042， China

doi：10.3969/j.issn.1674-4985.2021.01.012

急性支气管炎是临床常见的呼吸系统疾病，是由感染、物理、化学或过敏因素刺激引起的气管-支气管黏膜的急性炎症反应[1]，主要以咳嗽、发热、喘憋及肺部湿啰音为临床表现，好发于寒冷冬季或气温突然转冷时，婴幼儿与体质虚弱的老年人易发病[2]，本病起病急骤且病情变化快，甚至造成患者死亡。目前，临床治疗以药物治疗为主，但单一药物治疗效果欠佳，故本研究将肺力咳合剂联合喜炎平治疗，评估临床效果，现报道如下。

1 资料与方法

1.1 一般资料 回顾性选取2018年11月-2019年10月于本院就诊的急性支气管炎患者174例作为研究对象。（1）纳入标准：①参照《咳嗽的诊断与治疗指南》中急性支气管炎的相关诊断标准[3]，支气管舒张试验为阳性;②急性起病，病程<5 d;③未接收其他药物治疗。（2）排除标准：①对所用肺力咳合剂和喜炎平等药物过敏;②妊娠期或哺乳期;③存在严重精神疾病;④糖尿病或高血压控制不良。根据治疗方法将其分为试验组（n=89）和对照组（n=85）。本研究已经通过伦理学委员会批准。

1.2 方法 患者入院后均进行常规抗感染治疗，对照组给予喜炎平注射液（生产厂家：江西青峰药业有限公司，批准文号：国药准字Z20026249，规格：每支装2 mL︰50 mg;5 mL︰125 mg;10 mL︰250 mg）混合0.9%氯化钠100 mL静脉滴注治疗，250 mg/次，BID，连续治疗7 d。……