廖嘉宝 苏少婵 梁妍琨

【摘要】 目的：探討盐酸氨溴索注射液辅助治疗肺部感染的临床效果。方法：选取2019年1-12月本院收治的肺部感染患者74例为研究对象，按随机数字表法分为A组（n=37）和B组（n=37）。B组采用桉柠蒎肠溶软胶囊祛痰治疗，A组采用桉柠蒎肠溶软胶囊+氨溴索注射液祛痰治疗。比较两组疗效、相关症状缓解时间、治疗前后C反应蛋白（CRP）、白细胞计数（WBC）、中性粒细胞百分比、动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）、动脉血氧饱和度（SaO2）及不良反应发生情况。结果：A组治疗总有效率高于B组（P<0.05）。A组肺部啰音、咳嗽、气喘、咳痰及发热缓解时间均短于B组（P<0.05）。治疗后，A组PaO2与SaO2均高于B组，且CRP、WBC、中性粒细胞百分比及PaCO2均低于B组（P<0.05）。两组不良反应发生率比较，差异无统计学意义（P>0.05）。结论：盐酸氨溴索注射液辅助治疗肺部感染的效果和安全性良好，可有效改善患者临床症状、炎症和血气分析，值得推广应用。

【关键词】 盐酸氨溴索注射液 辅助治疗 肺部感染

Clinical Effect of Ambroxol Hydrochloride Injection in the Adjuvant Treatment of Pulmonary Infection/LIAO Jiabao， SU Shaochan， LIANG Yankun. //Medical Innovation of China， 2021， 18（01）： 0-046

[Abstract] Objective： To investigate the clinical effect of Ambroxol Hydrochloride Injection in the adjuvant treatment of pulmonary infection. Method： A total of 74 patients with pulmonary infection admitted to our hospital from January to December 2019 were selected as study subjects. They were divided into group A （n=37） and group B （n=37） according to the random number table method. Group B was treated with Eucalyptol， Limonene and Pinene Enteric Soft Capsules as expectorant. Group A was treated with Eucalyptol， Limonene and Pinene Enteric Soft Capsules+Ambroxol Hydrochloride Injection. The efficacy， remission time of related symptoms， C-reactive protein （CRP）， white blood cell count （WBC）， percentage of neutrophils， partial arterial oxygen pressure （PaO2）， partial arterial carbon dioxide （PaCO2）， arterial oxygen saturation （SaO2） before and after treatment and the occurrence of adverse reactions were compared between the two groups. Result： The total effective rate of group A was higher than group B （P<0.05）. The remission time of rhonchus， cough， asthma， expectoration and fever in group A were shorter than those in group B （P<0.05）. After treatment， both PaO2 and SaO2 in group A were higher than those in group B， and CRP， WBC， neutrophil percentage and PaCO2 were lower than those in group B （P<0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups （P>0.05）. Conclusion： Ambroxol Hydrochloride Injection applied in the adjuvant treatment of pulmonary infection has good efficacy and safety， which can effectively improve the clinical symptoms， inflammation and blood gas analysis of the patients. It is worthy of popularization and application.

[Key words] Ambroxol Hydrochloride Injection Adjuvant therapy Pulmonary infection

First-authors address： Shunde Hospital of Southern Medical University （The First Peoples Hospital of Shunde District）， Foshan 528308， China

doi：10.3969/j.issn.1674-4985.2021.01.011

肺部感染的发病率近年来呈现不断上升趋势，而耐药菌的产生进一步加重其治疗困难程度，肺部感染已成为严重威胁人类健康的病症[1]。肺部感染患者的呼吸内分泌物滞留可阻碍通气，造成肺通气功能降低和组织缺氧，因此其治疗过程中祛痰治疗是重要环节[2]。桉柠蒎肠溶软胶囊可通过β拟交感效应刺激纤毛摆动和增强纤毛活性，促进痰液排除，在肺部感染疾病中应用效果良好[3]。氨溴索为黏液溶解剂，可降低痰液黏度和促进支气管纤毛运动，可应用于肺部感染疾病祛痰干预中[4]。因此，本研究在抗生素抗感染、氧疗、退热、纠正水电解质酸碱紊乱等常规治疗以及桉柠蒎肠溶软胶囊祛痰的基础上，采用盐酸氨溴索注射液辅助治疗肺部感染患者，观察其对疗效、炎症、临床症状、血气分析等的影响以及其安全性，旨在为盐酸氨溴索注射液辅助治疗肺部感染的推广应用提供依据，现报道如下。……