徐健 周雪

【摘要】 目的：探讨对射血分数降低的心力衰竭患者应用沙库巴曲缬沙坦钠片联合心脏运动康复的临床效果。方法：选取2019年2月-2020年12月本院收治的104例HFrEF患者，将其随机分为对照组和观察组，每组52例。对照组使用常规治疗方式，观察组采取沙库巴曲缬沙坦钠片联合心脏运动康复。比较两组患者的应用效果。结果：观察组总有效率92.31%，高于对照组的71.15%，差异有统计学意义（P<0.05）。治疗后，观察组LVEDV、LEVF和LVESV、AT心率、峰值最大心率、AT摄氧量、峰值摄氧量、运动时间、6 min步行最大距离均明显优于对照组，差异均有统计学意义（P<0.05）。结论：对于射血分数降低的心力衰竭患者，应用沙库巴曲缬沙坦钠片联合心脏运动康复的方式，能够改善患者心功能和运动功能，提高治疗效果。

【关键词】 沙库巴曲缬沙坦钠片 心脏运动康复 心力衰竭 射血分数

Study on the Effect of Combined Therapy of Shakuba Valsartan Sodium Tablets and Cardiac Exercise Rehabilitation on Heart Failure with Low Ejection Fraction/XU Jian， ZHOU Xue. //Medical Innovation of China， 2021， 18（33）： -152

[Abstract] Objective： To investigate the clinical effect of Shakuba Valsartan Sodium Tablets combined with cardiac exercise rehabilitation in heart failure patients with decreased ejection fraction. Method： A total of 104 HFrEF patients admitted to our hospital from February 2019 to December 2020 were selected and randomly divided into control group and observation group， 52 cases in each group. The control group received conventional treatment， and the observation group received Shakuba Valsartan Sodium Tablets combined with cardiac exercise rehabilitation. The effect of application was compared between the two groups. Result： The total effective rate of observation group was 92.31%， which was higher than 71.15% of control group， the difference was statistically significant （P<0.05）. After treatment， LVEDV， LEVF and LVESV， AT heart rate， peak maximum heart rate， AT oxygen uptake， peak oxygen uptake， exercise time and maximum walking distance of 6 min in the observation group were significantly better than those in the control group， the differences were statistically significant （P<0.05）. Conclusion： For heart failure patients with decreased ejection fraction， the application of Shakuba Valsartan Sodium Tablets combined with cardiac exercise rehabilitation can improve the cardiac function and motor function of patients， and improve the therapeutic effect.

[Key words] Shakuba Valsartan Sodium Tablets Cardiac exercise rehabilitation Heart failure Ejection fraction

First-author’s address： Fengxian People’s Hospital， Fengxian 221700， China

doi：10.3969/j.issn.1674-4985.2021.33.036

心力衰竭（HF）多見于老年人，是多种心脏疾病发展至终末阶段的常见表现之一，表现为左心室和左心房压力增加，室壁增厚，心排血量下降[1-2]。在临床中会将左心室射血分数（LVEF）小于40%的心力衰竭称为射血分数降低的心力衰竭（HFrEF）。沙库巴曲缬沙坦（诺欣妥）是一种新型的血管紧张素受体脑啡肽阻断剂，能够缓解水钠潴留，改善心室重构等情况[3]。同时，近年来也有研究表明，心脏运动康复对于改善射血分数降低的心力衰竭患者有良好的治疗效果[4]。本次研究目的在于探讨沙库巴曲缬沙坦钠片与心脏运动康复联合应用对于射血分数降低的心力衰竭患者的治疗效果，本院对2019年2月-2020年12月入院的104例患者进行了对照研究，现报道如下。……