杨静 任星 杨巧宁 张菀桐 高蕊

摘要 目的：分析动脉粥样硬化动物实验的研究现状，寻求公认的造模方法。方法：在国家知识基础设施数据库（简称中国知网，CNKI）中检索近10年内动脉粥样硬化相关动物实验的文献，按照发表时间、发文类型、文献来源、模型动物种类、造模方法、造模时间、涉及治疗方法等进行分析。结果：共纳入2 709篇文献，1）涉及动脉粥样硬化治疗的文献有2 173篇;2）发文趋势整体较平稳;3）模型动物以ApoE-/-小鼠、SD大鼠、新西兰兔为主，其主要造模方法分别为单纯高脂饮食喂养、高脂饮食+腹腔注射维生素D3、高脂饮食+球囊损伤;4）中医药治疗动脉粥样硬化的动物实验已广泛开展。结论：目前涉及最多的动物模型是ApoE-/-小鼠，以单纯高脂饮食喂养为造模方法，造模时间集中在12周左右，且中医对于动脉粥样硬化的研究已深入开展，为其在临床中的广泛应用奠定基础。

关键词 动脉粥样硬化;动物实验;造模方法;动物模型;ApoE-/-小鼠;SD大鼠;新西兰兔;中医药

Bibliometric Analysis of Animal Experiments Related to Atherosclerosis Literature Based on CNKI Database

YANG Jing1，2，REN Xing2，YANG Qiaoning2，ZHANG Wantong2，GAO Rui2

（1 Graduate School of Beijing University of Chinese Medicine，Beijing 100029，China; 2 Xiyuan Hospital of China Academy of Chinese Medical Sciences，Beijing 100091，China）

Abstract Objective：To analyze the current research status of atherosclerosis in animal experiments and seek a recognized method for modeling.Methods：The CNKI database was searched for the literature on atherosclerosis-related animal experiments in the past ten years，and analyzed according to the publication time，type of publication，document source，type of model animal，modeling method，modeling time，and related treatment methods.Results：A total of 2 709 papers were included，1） 2 173 papers related to the treatment of atherosclerosis; 2） The publishing trend was generally stable; 3） Model animals were ApoE-/-mice，SD rats，and New Zealand rabbits.Mainly，the main modeling methods were simple high-fat diet feeding，high-fat diet+intraperitoneal injection of vitamin D3，high-fat diet+balloon injury; 4） Animal experiments on the treatment of atherosclerosis with traditional Chinese medicine have been widely carried out.Conclusion：At present，the most involved animal model is ApoE-/-mice.The model is made by feeding pure high-fat diet.The modelling time is concentrated at about 12 weeks，and the research on atherosclerosis in Chinese medicine has been deeply carried out，which laid the foundation for wide application in clinic.

Keywords Atherosclerosis; Animal experiments; Modeling method; Animal model; ApoE-/-mice; SD rats; New Zealand rabbits; Traditional Chinese medicine

中圖分类号：R256.22文献标识码：Adoi：10.3969/j.issn.1673-7202.2021.23.022

动脉粥样硬化（Atherosclerosis，AS）是一种多因素作用而成的疾病[1]，发病机制极其复杂，且目前治疗手段较为单一，以调节血脂为主。作为心脑血管疾患的关键危险因素[2]，医学界对于AS的重视程度只增不减，相继开展了众多动物实验研究，为解决AS的临床问题奠定基础。本研究基于中国知网（CNKI数据库），了解近10年AS动物实验的研究现状，并对动物造模等进行梳理，以寻求现有较公认、有效的造模方法[3]，为后期相关动物实验的开展提供参考。……